Evidence map›Paper›PMID 34012519›Full record

ArticleAvicenna journal of medical biotechnology

Using CRISPR/Cas9 System to Knock out Exon 48 in

Mahintaj Dara, Vahid Razban, Mahdieh Talebzadeh, Sepideh Moradi, Mehdi Dianatpour

Open access · greenAbstract read
In one paragraph

Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Identification of Two Novel Variants of thePharmacogenomics and personalized medicine · 2023
    Article
  3. CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mahintaj DaraDepartment of Molecular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Vahid RazbanDepartment of Molecular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahdieh TalebzadehDepartment of Molecular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sepideh MoradiDepartment of Molecular Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mehdi DianatpourDepartment of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOut of frame mutations in

methodsA pair of guide RNAs (gRNAs) was designed to cleave

resultsExon 48 was successfully deleted and therefore exon 47 was joined to exon 49.

conclusionThis result indicated that CRISPR/Cas9 system could be used to edit

Indexed as

CRISPR/Cas9DystrophinGene editingMuscular dystrophies

Identifiers

PMID34012519
PMCPMC8112140
OpenAlexW3132171260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.