Evidence map›Paper›PMID 34012494›Full record

ArticleDisease markers2021

Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population.

Yumin Zhou, Man Wang, Weiyan Yang, Jianjun Li, Jialin Li, Yueying Hu, Wei Wang, Chunli Che, Hong Qi

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yumin ZhouState Key Laboratory of Respiratory Disease, National Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Man WangHarbin Medical University, Harbin 150010, China.
Weiyan YangHarbin Medical University, Harbin 150010, China.
Jianjun LiHarbin Medical University, Harbin 150010, China.
Jialin LiDepartment of Respiratory Medicine, Southern University of Science & Technology Hospital, Shenzhen 518012, China.
Yueying HuHarbin Medical University, Harbin 150010, China.
Wei WangHarbin Medical University, Harbin 150010, China.
Chunli CheHarbin Medical University, Harbin 150010, China.ORCID https://orcid.org/0000-0002-7494-2354
Hong QiState Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.ORCID https://orcid.org/0000-0002-8868-5950
Harbin Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNHarbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a typical heterogeneous condition caused by environmental and genetic risk factors.

objectivesWe investigated extrinsic (environmental) and intrinsic (genetic) factors contributing to the development of COPD in a nonsmoker road-working population in Northeast China.

methodThe target population was divided into a COPD group and an exposed control group. Another healthy nonroad working nonsmoker control group was also included for environmental factor comparison. Peripheral blood was collected and analyzed using inductively coupled plasma mass spectrometry for inorganic elements of PM2.5, and microarray, rt-PCR, and Multiplex ELISA for genetic factors.

resultsForty-three COPD road workers, thirty-nine non-COPD road workers, and 52 age and gender-matched healthy nonroad workers were enrolled. There were significantly higher levels in all 24 inorganic elements in the COPD group compared with the healthy control group except potassium and manganese, while the majority of inorganic elements were similar between the COPD group and the exposed control group except in aluminum and cobalt. There were 39 genes showing significant differences between the COPD group and the exposed control group. Collagen, type XV, alpha 1 (COL15A1), Meis homeobox 1 (MEIS1), carbonyl reductase 3 (CBR3), and amine oxidase, copper containing 3 (AOC3) were confirmed by rt-PCR to be differentially expressed. Their correlations with blood cytokines were also evaluated.

conclusionsAluminum might contribute to the development of COPD in the road-working population. CBR3 and AOC3 seem expressed in different patterns than previously reported, evidenced by their correlation with proinflammatory and anti-inflammatory cytokines.

Indexed as

AdultAir PollutantsAlcohol OxidoreductasesAluminumAmine Oxidase (Copper-Containing)BiomarkersCell Adhesion MoleculesCollagenCytokinesFemaleHumansMaleMiddle AgedMyeloid Ecotropic Viral Integration Site 1 ProteinOccupational DiseasesOccupational ExposureAir PollutantsAlcohol OxidoreductasesAluminumAmine Oxidase (Copper-Containing)AOC3 protein, humanBiomarkersCBR3 protein, humanCell Adhesion MoleculesCollagenCytokinesMEIS1 protein, humanMyeloid Ecotropic Viral Integration Site 1 Protein

Identifiers

PMID34012494
PMCPMC8105110
OpenAlexW3157647930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.