Evidence map›Paper›PMID 34012469›Full record

ReviewStem cells international2021

Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues.

Ioannis Alexandros Charitos, Andrea Ballini, Stefania Cantore, Mariarosaria Boccellino, Marina Di Domenico, Elisa Borsani, Riccardo Nocini, Michele Di Cosola, Luigi Santacroce, Lucrezia Bottalico

Abstract readReview
In one paragraph

Review in Stem cells international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  17. Single-cell Technology in Stem Cell Research.Current stem cell research & therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ioannis Alexandros CharitosInterdepartmental Research Center for Pre-Latin, Latin and Oriental Rights and Culture Studies (CEDICLO), University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0003-3527-7483
Andrea BalliniDepartment of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario "Ernesto Quagliariello", University of Bari "Aldo Moro", Bari, Italy.ORCID https://orcid.org/0000-0001-8758-1415
Stefania CantoreDepartment of Interdisciplinary Medicine, University of Bari, School of Medicine, Bari, Italy.ORCID https://orcid.org/0000-0001-9521-2521
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0001-6989-010X
Marina Di DomenicoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-6201-4200
Elisa BorsaniDivision of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-9746-0876
Riccardo NociniSection of Ear Nose and Throat (ENT), Department of Surgical Sciences, Dentistry, Gynecology and Pediatric, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-5086-4390
Michele Di CosolaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-2756-3212
Luigi SantacroceDepartment of Interdisciplinary Medicine, University of Bari, School of Medicine, Bari, Italy.ORCID https://orcid.org/0000-0001-5671-8124
Lucrezia BottalicoInterdepartmental Research Center for Pre-Latin, Latin and Oriental Rights and Culture Studies (CEDICLO), University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0003-4176-3939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells can be used to replace damaged cells or regenerate organs and have broadened our knowledge of the development and progression of certain diseases. Despite significant advances in understanding stem cell biology, several problems limit their use. These problems are related not only to the growth of tumors in animal models and their rejection in transplant cases but also to ethical and social issues about the use of embryonic cells. The ethical-scientific debate on this type of cells has taken on great interest both for their application in regenerative medicine and for the potential possibilities in the field of cell and gene therapy. Different points of view often have the expression of a perception that depends on scientific goals or opportunities or on religious traditions and beliefs. Therefore, as the questions and doubts about when life begins, so do the answers for the use of these cells as therapy or otherwise. So, in addition to the origin of stem cells, there are currently some social bioethical (such as political and legislative issues) and religious dilemmas. The purpose of the study is aimed at being a narrative on the history of stem cells and the evolution of their use to date, as well as to clarify the bioethical position of the various religions today in comparison with the social ones regarding the research and use of embryonic and adult ones. Hence, their biological hypostasis regarding the concepts of "conception" and "fertilization" and their development and therapeutic use compared to those of the main theological doctrines.

Identifiers

PMID34012469
PMCPMC8105090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.