Evidence map›Paper›PMID 34012446›Full record

ArticleFrontiers in immunology2021

HLA-DR-Positive NK Cells Expand in Response to Mycobacterium Tuberculosis Antigens and Mediate Mycobacteria-Induced T Cell Activation.

Sofya A Kust, Maria A Streltsova, Alexander V Panteleev, Natalya L Karpina, Irina V Lyadova, Alexander M Sapozhnikov, Elena I Kovalenko

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. NK cells in HPV-related tumorigenesis: mechanisms and clinical applications.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Single-Cell Sequencing Reveals Functional Alterations in Tuberculosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Effect of Immunomodulating Extract and Some Isolates fromMolecules (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sofya A KustLaboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Science, Moscow, Russia.
Maria A StreltsovaLaboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Science, Moscow, Russia.
Alexander V PanteleevLaboratory of Biotechnology, Central Tuberculosis Research Institute, Moscow, Russia.
Natalya L KarpinaDiagnostic Outpatient Department, Central Tuberculosis Research Institute, Moscow, Russia.
Irina V LyadovaLaboratory of Biotechnology, Central Tuberculosis Research Institute, Moscow, Russia.
Alexander M SapozhnikovLaboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Science, Moscow, Russia.
Elena I KovalenkoLaboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Science, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NK cells play an important role in the control of tuberculosis infection: they are not only able to kill the infected cells, but also control the activity of macrophages and development of the adaptive immune response. Still, there is little information on the role of specific NK cell subsets in this network. In this study, we focused on the mycobacteria-driven responses of the NK cells expressing HLA-DR - a type of MHC class II. We have revealed that this subset is increased in the peripheral blood of patients with primary diagnosed tuberculosis, and expands in response to

Indexed as

Adaptive ImmunityAntigens, BacterialHLA-DR AntigensHumansInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMycobacteriumPhenotypeT-LymphocytesAntigens, BacterialHLA-DR AntigensInterferon-gammaMycobacterium tuberculosis antigensantigen presentationCD4+ T cellsIFNγMycobacterium tuberculosisNK cells

Identifiers

PMID34012446
PMCPMC8128146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.