Evidence map›Paper›PMID 34012439›Full record

ArticleFrontiers in immunology2021

Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype.

Hamid R Razzaghian, Zohreh Sharafian, Ashish A Sharma, Guilaine K Boyce, Kelsey Lee, Rachel Da Silva, Paul C Orban, Rafick-Pierre Sekaly, Colin J Ross, Pascal M Lavoie

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hamid R RazzaghianBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Zohreh SharafianBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Ashish A SharmaBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Guilaine K BoyceBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Kelsey LeeBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Rachel Da SilvaBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Paul C OrbanBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Rafick-Pierre SekalyDepartment of Pathology & Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA, United States.
Colin J RossBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Pascal M LavoieBC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
BC Children's Hospital · CAUniversity of British Columbia · CAEmory University · US

Funding

CIHR MOP-110938CIHR MOP-123478CIHR PJT-165943
6 · The paper itself

Abstract

Newborns are frequently affected by mucocutaneous candidiasis. Th17 cells essentially limit mucosal invasion by commensal

Indexed as

ImmunomodulationAge FactorsCell DifferentiationCytokinesHumansInfant, NewbornInterleukin-22InterleukinsLymphocyte ActivationSTAT3 Transcription FactorTh17 CellsT-Lymphocyte SubsetsTransforming Growth Factor betaCytokinesInterleukin-22InterleukinsSTAT3 protein, humanSTAT3 Transcription FactorTransforming Growth Factor betagene regulationneonatalStat3T cellsTGF-β signalingT helper (Th) 17 cells

Identifiers

PMID34012439
PMCPMC8126652
OpenAlexW3159046749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.