Evidence map›Paper›PMID 34012438›Full record

ReviewFrontiers in immunology2021

Resident Memory T Cells in Autoimmune Skin Diseases.

Grace E Ryan, John E Harris, Jillian M Richmond

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
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  8. CD8MedComm · 2026
    Review
  9. Observational
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Grace E RyanDepartment of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
John E HarrisDepartment of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
Jillian M RichmondDepartment of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · US

Funding

Treg Migration and Function During Autoimmunity within Peripheral TissueR01AR069114 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARRIS, JOHN E · 2015 to 2020
$2.2M
NIAMS NIH HHS R01 AR069114
6 · The paper itself

Abstract

Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.

Indexed as

AutoantigensAutoimmune DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansImmunologic FactorsImmunologic MemorySkinSkin DiseasesAutoantigensImmunologic Factorsalopeciaautoimmunitycutaneous lupus erythematosus (CLE)dermatologypsoriasisresident memory T cell (TRM)vitiligo

Identifiers

PMID34012438
PMCPMC8128248
OpenAlexW3159116143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.