Evidence map›Paper›PMID 34012434›Full record

ArticleFrontiers in immunology2021

3D Bioprinting Allows the Establishment of Long-Term 3D Culture Model for Chronic Lymphocytic Leukemia Cells.

Francesca Vittoria Sbrana, Riccardo Pinos, Federica Barbaglio, Davide Ribezzi, Fiorella Scagnoli, Lydia Scarfò, Itedale Namro Redwan, Hector Martinez, Silvia Farè, Paolo Ghia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 48 citations in OpenAlex.

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  15. Extrusion bioprinting: meeting the promise of human tissue biofabrication?Progress in biomedical engineering (Bristol, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Francesca Vittoria SbranaMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
Riccardo PinosMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
Federica BarbaglioMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
Davide RibezziMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
Fiorella ScagnoliMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
Lydia ScarfòSchool of Medicine, Università Vita-Salute San Raffaele, Milano, Italy.
Itedale Namro RedwanCELLINK AB, Gothenburg, Sweden.
Hector MartinezCELLINK AB, Gothenburg, Sweden.
Silvia FarèDepartment of Chemistry, Materials and Chemical Engineering, Politecnico di Milano, Milano, Italy.
Paolo GhiaSchool of Medicine, Università Vita-Salute San Raffaele, Milano, Italy.
Cristina ScielzoMalignant B Cells Biology and 3D Modelling Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano, Italy.
IRCCS Ospedale San Raffaele · ITPolitecnico di Milano · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Lymphocytic Leukemia (CLL) represents the most common leukemia in the western world and remains incurable. Leukemic cells organize and interact in the lymphoid tissues, however what actually occurs in these sites has not been fully elucidated yet. Studying primary CLL cells

Indexed as

BioprintingCell AdhesionCell Culture TechniquesCell Line, TumorCell SurvivalChemokinesDNA ReplicationGene ExpressionHumansHydrogelsLeukemia, Lymphocytic, Chronic, B-CellPrinting, Three-DimensionalTissue ScaffoldsChemokinesHydrogels3D cultureB cellbioprintingchronic lymphocytic leukemialeukemia

Identifiers

PMID34012434
PMCPMC8126722
OpenAlexW3158366345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.