ReviewFrontiers in endocrinology2021
Oncocytic Change in Thyroid Pathology.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Conventional sonographic phenotype of thyroid oncocytic neoplasms: a pathology-confirmed comparative study.Journal of ultrasound · 2026Article
- Survival outcomes, metastatic patterns, and local invasion in oncocytic papillary thyroid carcinomas and oncocytic carcinomas: A retrospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Clinical Impact of Rare Subtypes of Parathyroid Adenoma: A Systematic Review.Journal of personalized medicine · 2026Review
- Significance of Oncocytic Cells in Thyroid Fine Needle Aspiration Specimens Classified as Atypia of Undetermined Significance.Turk patoloji dergisi · 2026Article
- Review
- The Role of Mitochondrial Genome Stability and Metabolic Plasticity in Thyroid Cancer.Biomedicines · 2025Review
- Multimodal model enhances qualitative diagnosis of hypervascular thyroid nodules: integrating radiomics and deep learning features based on B-mode and PDI images.Gland surgery · 2025Article
- Cytopathology of follicular and oncocytic follicular thyroid neoplasms: A Bethesda System perspective.Cancer cytopathology · 2025Review
- Navigating Diagnostic Uncertainty in Thyroid Nodules: The Critical Role of Cytology and Histology in Oncocytic and Rare Patterned Lesions.Cytopathology : official journal of the British Society for Clinical Cytology · 2025Article
- Lymphocytic thyroiditis with an oncocytic alteration in a laboratory beagle.Journal of toxicologic pathology · 2025Article
- Differential diagnosis of Hashimoto's thyroiditis: The importance of pathological anatomy.Journal of biological methods · 2025Review
- Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors.Endocrine pathology · 2024Article
- Clinicopathological and Radiological Correlation Among the Spectrum of Nodular Thyroid Lesions.Cureus · 2024Article
- Article
- N-Nitrosomorpholine-induced oncocytic transformation in rat endocrine organs.European journal of medical research · 2024Article
- Comparison of ultrasound findings of papillary thyroid carcinoma subtypes based on the 2022 WHO classification of thyroid neoplasms.Frontiers in endocrinology · 2024Article
- A clinically applicable molecular classification of oncocytic cell thyroid nodules.Endocrine-related cancer · 2023Article
- Top Ten Oncocytic Head and Neck Lesions to Contemplate.Head and neck pathology · 2023Review
- Characterization of metabolic reprogramming by metabolomics in the oncocytic thyroid cancer cell line XTC.UC1.Scientific reports · 2023Article
- Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncocytes are cells that have abundant eosinophilic cytoplasm due to the accumulation of mitochondria; they are also known as oxyphils. In the thyroid they have been called Hürthle cells but this is a misnomer, since Hürthle described C cells; for this reason, we propose the use of "oncocyte" as a scientific term rather than an incorrect eponym. Oncocytic change occurs in nontumorous thyroid disorders, in benign and malignant tumors of thyroid follicular cells, in tumors composed of thyroid C cells, and intrathyroidal parathyroid proliferations as well as in metastatic lesions. The morphology of primary oncocytic thyroid tumors is similar to that of their non-oncocytic counterparts but also is complicated by the cytologic features of these cells that include both abundant eosinophilic cytoplasm and large cherry red nucleoli. The molecular alterations in oncocytic thyroid tumors echo those of their non-oncocytic counterparts but in addition feature mitochondrial DNA mutations as well as chromosomal gains and losses. In this review we emphasize the importance of recognition of the spectrum of oncocytic thyroid pathology. The cell of origin, morphologic features including architecture, nuclear atypia and invasive growth, as well as high grade features such as mitoses and necrosis, enable accurate classification of these lesions. The molecular alterations underlying the pathological entity are associated with genetic alterations associated with oncocytic change. The arbitrary cut-off of 75% oncocytic change to classify a lesion as an oncocytic variant brings another complexity to the classification scheme of tumors that frequently have mixed oncocytic and non-oncocytic components. This controversial and often confusing area of thyroid pathology requires thoughtful and cautious investigation to clarify accurate diagnosis, prognosis and prediction for patients with oncocytic thyroid lesions.
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