Evidence map›Paper›PMID 34012400›Full record

ReviewFrontiers in pharmacology2021

Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers.

Yan Chang, Souvik Roy, Zui Pan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. The function of chloride channels in digestive system disease (Review).International journal of molecular medicine · 2025
    Review
  3. Article
  4. Article
  5. Crosstalk between CaInternational journal of molecular sciences · 2022
    Review
  6. Science CommuniCaCells · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. The Important Role of Ion Transport System in Cervical Cancer.International journal of molecular sciences · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yan ChangCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, United States.
Souvik RoyDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX, United States.
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, United States.
The University of Texas at Arlington · US

Funding

Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
An Inverted Nikon A1R Laser Scanning Confocal MicroscopeS10OD025230 · OD · UNIVERSITY OF TEXAS ARLINGTON · PI PAN, ZUI · 2019 to 2019
$449k
NCI NIH HHS R01 CA185055NIH HHS S10 OD025230
6 · The paper itself

Abstract

Gastroesophageal cancers, including tumors occurring in esophagus and stomach, usually have poor prognosis and lack effective chemotherapeutic drugs for treatment. The association between dysregulated store-operated calcium entry (SOCE), a key intracellular Ca

Indexed as

calcium signalingcancer stem cellsdrug resistanceesophageal squamous cell carcinomaorai

Identifiers

PMID34012400
PMCPMC8126661
OpenAlexW3158150405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.