ArticleInternational journal of general medicine2021
International Normalized Ratio to Albumin Ratio (PTAR): An Objective Risk Stratification Tool in Patients with Sepsis.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Prognostic Significance of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in Cancer Patients with Complication of Sepsis: A Retrospectively Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Article
- Article
- Observational
- Association between international normalized ratio-to-albumin ratio and mortality in critically ill patients with gastrointestinal bleeding: a retrospective MIMIC-IV database study.BMC gastroenterology · 2025Article
- Prognostic value of the international normalized ratio to albumin ratio in acute pancreatitis: insights from MIMIC-IV database.BMC gastroenterology · 2025Article
- Evaluating the Performance of Four Risk Assessment Scores in Nonvariceal Upper Gastrointestinal Bleeding.Cureus · 2025Article
- Interpretations of the Role of Plasma Albumin in Prognostic Indices: A Literature Review.Journal of clinical medicine · 2023Review
- Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Construction and dual internal validation of a short-term prognostic scoring tool for sepsis.Heliyon · 2023Article
- Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.International journal of general medicine · 2023Article
- International Normalized Ratio-to-Albumin Ratio as a Novel Marker of Upper Gastrointestinal Bleeding Severity.Gastroenterology research and practice · 2022Article
- Relationship Between International Normalized Ratio to Albumin Ratio and Mortality in Critically Ill Patients With Myocardial Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a life-threatening multiple-organ dysfunction caused by dysregulation of host response to severe infection. Liver failure is a validated independent predictor of mortality. Accurate and rapid assessment of liver function is critical in patients with sepsis. However, an appropriate scoring system for liver function requires further development.
objectiveOur study aimed to validate the usefulness of the prothrombin time-international normalized ratio (PT-INR) to albumin ratio (PTAR) in predicting the mortality of patients with sepsis.
methodsData on a total of 4536 patients, obtained from the Multiparameter Intelligent Monitoring in Intensive Care III database, were included in our retrospective study. Logistic regression, Poisson regression with robust variance estimate analysis, and Cox proportional hazards models were used to explore the relationship between PTAR and mortality. Area under the curve (AUC) and decision curve analysis (DCA) were used to estimate the performance of PTAR in predicting the prognosis in septic patient.
resultsMultivariable Poisson regression showed that the relative risk (RR) of PTAR to ICU mortality, hospital mortality, and 28-day and 90-day mortality in septic patients was 1.26 (95% CI: 1.15-1.37), 1.24 (95% CI: 1.15-1.34), 1.23 (95% CI: 1.15-1.31), and 1.21 (95% CI: 1.13-1.28), respectively. Multivariable Cox regression showed that the hazard ratio (HR) of PTAR to 28-day mortality and 90-day mortality was 1.56 (95% CI: 1.44-1.70), and 1.55 (95% CI: 1.43-1.68), respectively. PTAR showed a moderate discrimination capacity in predicting hospital mortality (AUC: 0.655, 95% CI: 0.636-0.675) and 90-day mortality (AUC: 0.650, 95% CI: 0.633-0.667).
conclusionThe PTAR scoring system is a convenient tool for predicting the prognosis of patients with sepsis.
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