Evidence map›Paper›PMID 34012115›Full record

ArticleNature2021

Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection.

Elsje G Otten, Emma Werner, Ana Crespillo-Casado, Keith B Boyle, Vimisha Dharamdasani, Claudio Pathe, Balaji Santhanam, Felix Randow

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed
48.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 378 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. RNF213-dependent lytic destruction ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Targeting of ELMO2 by thebioRxiv : the preprint server for biology · 2026
    Article
  18. Substrate biasing in UCHL5 proteoforms.bioRxiv : the preprint server for biology · 2026
    Article
  19. Review
  20. Article

183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Elsje G Otten *MRC Laboratory of Molecular Biology, Cambridge, UK. gotten@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0002-8716-3560
Emma Werner *MRC Laboratory of Molecular Biology, Cambridge, UK.
Ana Crespillo-CasadoMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-7230-3188
Keith B BoyleMRC Laboratory of Molecular Biology, Cambridge, UK.
Vimisha DharamdasaniMRC Laboratory of Molecular Biology, Cambridge, UK.
Claudio PatheMRC Laboratory of Molecular Biology, Cambridge, UK.
Balaji SanthanamMRC Laboratory of Molecular Biology, Cambridge, UK.
Felix RandowMRC Laboratory of Molecular Biology, Cambridge, UK. randow@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0003-0694-5315
MRC Laboratory of Molecular Biology · GBSt. Jude Children's Research Hospital · US

Funding

Medical Research Council MC_U105170648MRF_ MRF-104-0004-S-PATHEWellcome Trust 104752Wellcome Trust WT104752MA
6 · The paper itself

Abstract

Ubiquitylation is a widespread post-translational protein modification in eukaryotes and marks bacteria that invade the cytosol as cargo for antibacterial autophagy

Indexed as

Salmonella typhimuriumUbiquitinationAdenosine TriphosphatasesAnimalsAutophagyCell LineHeLa CellsHumansLipopolysaccharidesMiceRING Finger DomainsSalmonella InfectionsUbiquitinUbiquitin-Protein LigasesAdenosine TriphosphatasesLipopolysaccharidesRNF213 protein, humanRNF213 protein, mouseUbiquitinUbiquitin-Protein Ligases

Identifiers

PMID34012115
PMCPMC7610904
OpenAlexW3160147040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.