ArticleNature2021
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The Association and Prognostic Implications of Long Non-Coding RNAs in Major Psychiatric Disorders, Alzheimer's Diseases and Parkinson's Diseases: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- lncRNAs: key player in Aβ deposition.RNA biology · 2026Review
- Programmed Double-stranded RNA Formation Enables Meiotic Stage Transitions.bioRxiv : the preprint server for biology · 2026Article
- Role of ncRNAs in Neurological Disorders and Cardiovascular Diseases.Experientia supplementum (2012) · 2026Review
- The hidden power of antisense long non-coding RNAs: a dive into a novel regulatory layer mediated by double-stranded RNA formation.RNA biology · 2025Review
- Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome.Nature communications · 2025Article
- Review
- Article
- Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies.Frontiers in aging neuroscience · 2025Review
- Single chromatin fiber profiling and nucleosome position mapping in the human brain.Cell reports methods · 2024Article
- Natural antisense transcripts as versatile regulators of gene expression.Nature reviews. Genetics · 2024Review
- The Association between Long Non-Coding RNAs and Alzheimer's Disease.Brain sciences · 2024Review
- Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription.Acta neuropathologica communications · 2024Article
- HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner.Cancer science · 2024Article
- The seeds of its regulation: Natural antisense transcripts as single-gene control switches in neurodegenerative disorders.Ageing research reviews · 2024Review
- Article
- Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases.Molecular neurodegeneration · 2024Review
- Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation.Theranostics · 2024Article
- Emerging perspectives on precision therapy for Parkinson's disease: multidimensional evidence leading to a new breakthrough in personalized medicine.Frontiers in aging neuroscience · 2024Review
- Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.Molecular psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 8 institutions in 5 countries.
Roberto SimoneReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK. r.simone@ucl.ac.uk.ORCID http://orcid.org/0000-0002-7722-1093
Faiza JavadReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-5215-6678
Warren EmmettUCL Genetics Institute, London, UK.
Oscar G WilkinsDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Filipa Lourenço AlmeidaReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-1710-9841
Natalia Barahona-TorresDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-5289-4232
Justyna Zareba-PaslawskaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6193-5908
Mazdak EhteramyanReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Paola ZuccottiDepartment of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Angelika ModelskaDepartment of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.ORCID http://orcid.org/0000-0001-6544-1024
Kavitha SivaDepartment of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Gurvir S VirdiDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-8942-0903
Jamie S MitchellDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-6954-9988
Jasmine HarleyDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Victoria A KayReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Geshanthi HondhamuniReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Daniah TrabzuniDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-4826-9570
Mina RytenDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0001-9520-6957
Selina WrayReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-3062-7050
Elisavet PrezaReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Demis A KiaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Alan PittmanGenetics Research Centre, Molecular and Clinical Sciences, St George's University of London, London, UK.ORCID http://orcid.org/0000-0002-8112-2987
Raffaele FerrariDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Claudia ManzoniUCL School of Pharmacy, Department of Pharmacology, London, UK.
Andrew LeesReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
John A HardyReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Michela A DentiDepartment of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Alessandro QuattroneDepartment of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Rickie PataniDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-3825-7675
Per SvenningssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Thomas T WarnerReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0001-6195-6995
Vincent PlagnolUCL Genetics Institute, London, UK.ORCID http://orcid.org/0000-0002-5597-9215
Jernej UleDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-2452-4277
Rohan de SilvaReta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK. r.desilva@ucl.ac.uk.ORCID http://orcid.org/0000-0002-5052-5775
National Hospital for Neurology and Neurosurgery · GBThe Francis Crick Institute · GBKarolinska Institutet · SEQueen Mary University of London · GBUniversity College London · GBBabraham Institute · GBHong Kong University of Science and Technology · HKSt George's, University of London · GB
Funding
Cancer Research UK FC001002Medical Research Council G0501560Medical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L023784/2Medical Research Council MR/L501542/1Medical Research Council MR/M02492X/1Medical Research Council MR/N008324/1Medical Research Council MR/N026004/1Medical Research Council MR/S006591/1Parkinson's UK G-0907Parkinson's UK G-1307Parkinson's UK K-1212Wellcome TrustWellcome Trust 202903/Z/16/Z
Abstract
The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes
Indexed as
AgedAnimalsBinding SitesBrainCase-Control StudiesCell DifferentiationDisease ProgressionFemaleHumansInternal Ribosome Entry SitesMaleMiceMice, TransgenicMiddle AgedNeuronsProtein BiosynthesisInternal Ribosome Entry SitesMAPT protein, humanRNA, Antisensetau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.