Evidence map›Paper›PMID 34012085›Full record

ArticleNature2021

Discovery, characterization and engineering of ligases for amide synthesis.

Michael Winn, Michael Rowlinson, Fanghua Wang, Luis Bering, Daniel Francis, Colin Levy, Jason Micklefield

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genome Mining of Isoindolinone-Containing Peptide Natural Products.Journal of the American Chemical Society · 2025
    Article
  7. Enzymatic Cascades for Stereoselective and Regioselective Amide Bond Assembly.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. NewSynthetic and systems biotechnology · 2024
    Article
  12. Enzymatic synthesis of peptide therapeutics.Nature chemical biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Enzymatic Fluoromethylation as a Tool for ATP-Independent Ligation.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  18. Enzymatic Fluoromethylation as a Tool for ATP-Independent Ligation.Angewandte Chemie (International ed. in English) · 2024
    Article
  19. Semirational engineering ofApplied and environmental microbiology · 2023
    Article
  20. Koninginins X-Z, Three New Polyketides fromMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael WinnDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Michael RowlinsonDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Fanghua WangDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Luis BeringDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Daniel FrancisDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Colin LevyDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.
Jason MicklefieldDepartment of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK. jason.micklefield@manchester.ac.uk.ORCID http://orcid.org/0000-0001-8951-4873

Funding

Biotechnology and Biological Sciences Research Council BB/K002341/1
6 · The paper itself

Abstract

Coronatine and related bacterial phytotoxins are mimics of the hormone jasmonyl-L-isoleucine (JA-Ile), which mediates physiologically important plant signalling pathways

Indexed as

AmidesAmino AcidsAzospirillum lipoferumCarboxylic AcidsCyclopentanesEscherichia coliHerbicidesIndenesIsoleucineKineticsLigasesModels, MolecularPectobacteriumPseudomonas syringaeAmidesAmino AcidsCarboxylic AcidscoronatineCyclopentanesHerbicidesIndenesIsoleucinejasmonoyl-isoleucineLigases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.