Evidence map›Paper›PMID 34012056›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2021

Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?

Prashant Agarwal, Girija Natarajan, Kevin Sullivan, Rakesh Rao, Natalie Rintoul, Isabella Zaniletti, Sarah Keene, Ulrike Mietzsch, An N Massaro, Zeenia Billimoria and 8 more

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trends in Neonatal Extracorporeal Membrane Oxygenation During a Venovenous Cannula Shortage.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Prashant AgarwalDepartment of Pediatrics, Children's Hospital of Michigan/Central Michigan University, Detroit, MI, USA. pagarwal@dmc.org.ORCID http://orcid.org/0000-0002-2656-5101
Girija NatarajanDepartment of Pediatrics, Children's Hospital of Michigan/Central Michigan University, Detroit, MI, USA.
Kevin SullivanDepartment of Pediatrics, AI duPont Hospital for Children/Thomas Jefferson University, Wilmington, DE, USA.ORCID http://orcid.org/0000-0002-4801-137X
Rakesh RaoDepartment of Pediatrics, Washington University in St. Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8250-1858
Natalie RintoulDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Isabella ZanilettiChildren's Hospital Association, Lenexa, KS, USA.ORCID http://orcid.org/0000-0003-1234-3468
Sarah KeeneDepartment of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA.
Ulrike MietzschDepartment of Pediatrics, Seattle Children's Hospital/University of Washington, Seattle, WA, USA.
An N MassaroDepartment of Pediatrics, The George Washington University School of Medicine and Children's National Hospital, Washington DC, DC, USA.ORCID http://orcid.org/0000-0002-5543-6165
Zeenia BillimoriaDepartment of Pediatrics, Seattle Children's Hospital/University of Washington, Seattle, WA, USA.
Daniel DirnbergerDepartment of Pediatrics, AI duPont Hospital for Children, Wilmington, DE, USA.
Shannon HamrickDepartment of Pediatrics, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA.
Ruth B SeabrookDepartment of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0352-2651
Mark F WeemsDepartment of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3518-8376
John P ClearyDepartment of Pediatrics, Children's Hospital of Orange County, Orange, CA, USA.
Brian W GrayDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Robert DiGeronimoDepartment of Pediatrics, Seattle Children's Hospital/University of Washington, Seattle, WA, USA.
Children’s Hospital Neonatal Consortium (CHNC) ECMO and HIE focus groups

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur hypothesis was that among infants with hypoxic-ischemic encephalopathy (HIE), venoarterial (VA), compared to venovenous (VV), extracorporeal membrane oxygenation (ECMO) is associated with an increased risk of mortality or intracranial hemorrhage (ICH). DESIGN/

methodsRetrospective cohort analysis of infants in the Children's Hospitals Neonatal Database from 2010 to 2016 with moderate or severe HIE, gestational age ≥36 weeks, and ECMO initiation <7 days of age. The primary outcome was mortality or ICH.

resultsSevere HIE was more common in the VA ECMO group (n = 57), compared to the VV ECMO group (n = 53) (47.4% vs. 26.4%, P = 0.02). VA ECMO was associated with a significantly higher risk of death or ICH [57.9% vs. 34.0%, aOR 2.39 (1.08-5.28)] and mortality [31.6% vs. 11.3%, aOR 3.06 (1.08-8.68)], after adjusting for HIE severity.

conclusionsIn HIE, VA ECMO was associated with a higher incidence of mortality or ICH. VV ECMO may be beneficial in this population.

Indexed as

Extracorporeal Membrane OxygenationHypoxia-Ischemia, BrainChildCohort StudiesHumansInfantInfant, NewbornIntracranial HemorrhagesRetrospective Studies

Identifiers

PMID34012056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.