Evidence map›Paper›PMID 34012043›Full record

ArticleScientific reports2021

MMP20-generated amelogenin cleavage products prevent formation of fan-shaped enamel malformations.

John D Bartlett, Charles E Smith, Yuanyuan Hu, Atsushi Ikeda, Mike Strauss, Tian Liang, Ya-Hsiang Hsu, Amanda H Trout, David W McComb, Rebecca C Freeman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Citrate Transporter NaCT and Enamel Mineralization: TheInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Challenges of Studying Amelogenesis in Gene-Targeted Mouse Models.International journal of molecular sciences · 2025
    Review
  5. Article
  6. ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation.International journal of molecular sciences · 2024
    Article
  7. International journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Enamel defects in Acp4Scientific reports · 2022
    Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

John D BartlettDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, USA.
Charles E SmithDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA.
Yuanyuan HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA.
Atsushi IkedaDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, USA.
Mike StraussDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Tian LiangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA.
Ya-Hsiang HsuDepartment of Materials Science and Engineering, Ohio State University College of Engineering, Columbus, OH, USA.
Amanda H TroutDepartment of Materials Science and Engineering, Ohio State University College of Engineering, Columbus, OH, USA.
David W McCombDepartment of Materials Science and Engineering, Ohio State University College of Engineering, Columbus, OH, USA.
Rebecca C FreemanDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA. jsimmer@umich.edu.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1210 Eisenhower Pl, Ann Arbor, MI, 48108, USA.
The Ohio State University · USUniversity of Michigan–Ann Arbor · USMcGill University · CA

Funding

Proteomics and Genetics of Enamel and DentinR01DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2004 to 2019
$5.7M
Enamelysin Processing Mechanisms in AmelogenesisR01DE028297 · NIDCR · OHIO STATE UNIVERSITY · PI BARTLETT, JOHN D · 2019 to 2023
$2.7M
Genetic Mechanisms of Amelogenesis ImperfectaR56DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2021 to 2021
$402k
NIDCR NIH HHS R01 DE015846NIDCR NIH HHS R01 DE028297NIDCR NIH HHS R56 DE015846
6 · The paper itself

Abstract

Dental enamel forms extracellularly as thin ribbons of amorphous calcium phosphate (ACP) that initiate on dentin mineral in close proximity to the ameloblast distal membrane. Secreted proteins are critical for this process. Enam

Indexed as

AmelogenesisAmeloblastsAmelogeninAnimalsDental EnamelDental Enamel ProteinsIncisorMatrix Metalloproteinase 20MiceAmelogeninAmelx protein, mouseDental Enamel ProteinsMatrix Metalloproteinase 20Mmp20 protein, mousetuftelin

Identifiers

PMID34012043
PMCPMC8134442
OpenAlexW3160357822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.