ArticleScientific reports2021
Directed evolution of Metarhizium fungus improves its biocontrol efficacy against Varroa mites in honey bee colonies.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Dose-dependent efficacy of a novel dsRNA-based solution containing vadescana for Varroa destructor control.Pest management science · 2026Article
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Fungal Pathogen Infection byBiology · 2025Article
- Mycelial Beehives of HIVEOPOLIS: Designing and Building Therapeutic Inner Nest Environments for Honeybees.Biomimetics (Basel, Switzerland) · 2022Article
- Frontiers in effective control of problem parasites in beekeeping.International journal for parasitology. Parasites and wildlife · 2022Article
- Entomopathogenic Fungi for Pests and Predators Control in Beekeeping.Veterinary sciences · 2022Review
- Marker assisted selection for Varroa destructor resistance in New Zealand honey bees.PloS one · 2022Article
- Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entomopathogenic fungi show great promise as pesticides in terms of their relatively high target specificity, low non-target toxicity, and low residual effects in agricultural fields and the environment. However, they also frequently have characteristics that limit their use, especially concerning tolerances to temperature, ultraviolet radiation, or other abiotic factors. The devastating ectoparasite of honey bees, Varroa destructor, is susceptible to entomopathogenic fungi, but the relatively warm temperatures inside honey bee hives have prevented these fungi from becoming effective control measures. Using a combination of traditional selection and directed evolution techniques developed for this system, new strains of Metarhizium brunneum were created that survived, germinated, and grew better at bee hive temperatures (35 °C). Field tests with full-sized honey bee colonies confirmed that the new strain JH1078 is more virulent against Varroa mites and controls the pest comparable to current treatments. These results indicate that entomopathogenic fungi are evolutionarily labile and capable of playing a larger role in modern pest management practices.
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