Evidence map›Paper›PMID 34011960›Full record

ArticleNature communications2021

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.

John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P Fahlman and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

John Maringa GithakaDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Namita TripathiDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Raven KirschenmanDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Namrata PatelDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Vrajesh PandyaDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
David A KramerDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-2434-3764
Rachel MontpetitDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Lin Fu ZhuDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-1478-9749
Nahum SonenbergDepartment of Biochemistry, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-4707-8759
Richard P FahlmanDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-4104-6374
Nika N DanialDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4842-1827
D Alan UnderhillDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Ing Swie GopingDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada. igoping@ualberta.ca.ORCID http://orcid.org/0000-0001-6355-827X
University of Alberta · CADana-Farber Cancer Institute · USMcGill University · CA

Funding

Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
CIHRNCI NIH HHS R50 CA221675
6 · The paper itself

Abstract

Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SubstitutionAnimalsbcl-Associated Death ProteinCell Cycle ProteinsCell LineCell MovementFemaleGene Knock-In TechniquesHumansMammary Glands, AnimalMammary Glands, HumanMiceMice, Inbred C57BLMice, KnockoutModels, AnimalAdaptor Proteins, Signal TransducingBAD protein, humanBad protein, mousebcl-Associated Death ProteinCell Cycle ProteinsEIF4EBP1 protein, humanEif4ebp1 protein, mouseMutant ProteinsRNA, MessengerSerine

Identifiers

PMID34011960
PMCPMC8134504
OpenAlexW3161504276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.