Evidence map›Paper›PMID 34011736›Full record

Trial reportIndian journal of ophthalmology2021

The effect of corneal crosslinking on the rigidity of the cornea estimated using a modified algorithm for the Schiøtz tonometer.

Larysa Tutchenko, Sudi Patel, Mykhailo Skovron, Olha Horak, Oleksiy Voytsekhivskyy

Open access · diamondAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Larysa TutchenkoDepartment of Ophthalmology, Shupyk National Medical Academy of Postgraduate Education; Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.
Sudi PatelNHS National Services Scotland, Edinburgh, UK.
Mykhailo SkovronKyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.
Olha HorakKyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.
Oleksiy VoytsekhivskyyKyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.
Kyiv City Clinical Oncology Center · UANational Health Service Scotland · GBShupyk National Healthcare University of Ukraine · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The aim of this study was to test a method for estimating corneal rigidity before and after cross-linking (CXL) using a Schiøtz tonometer. Methods: The study was performed in the Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Ukraine. This was a prospective, consecutive, randomized, masked, case-by-case, clinical study. Corneal rigidity, indicated by the gradient (G) between lg applied weight and corresponding lg scale reading during Schiøtz tonometry, were obtained by increasing (A-mode) then reducing (D-mode) weights by two operators [A] in keratoconus, post-CXL and control subjects for estimation of (i) interoperator and (ii) intersessional errors, (iii) intergroup differences; [B] before and after CXL. Central corneal thickness CCT was measured by scanning slit pachymetry. ANOVA, t tests, linear regression were the statistical tools used. Results: Average interoperator difference (ΔG) was -0.120 (SD = ±0.294, 95%CI = -0.175 to -0.066). A significant correlation between ΔG and the mean of each pair of G values was found (r = -0.196, n = 112, P = 0.038). Intersessional differences in mean G values were insignificant (P > 0.05). There was a significant correlation between G at first session (X Conclusion: Corneal rigidity (G) estimated using the Schiøtz tonometer can be useful for detecting changes after CXL. However, G values are linked to CCT, can vary from time-to-time and the procedure is operator dependent.

Indexed as

KeratoconusRiboflavinAlgorithmsCollagenCorneaCorneal PachymetryCross-Linking ReagentsHumansPhotosensitizing AgentsProspective StudiesUltraviolet RaysCollagenCross-Linking ReagentsPhotosensitizing AgentsRiboflavinCorneaCXLrigiditySchiøtz tonometer

Identifiers

PMID34011736
PMCPMC8302317
OpenAlexW3160260197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.