Evidence map›Paper›PMID 34011569›Full record

ArticleMolecular pharmacology2021

Antidepressants Produce Persistent G

Nicolas B Senese, Mark M Rasenick

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Rafting toward a depression biomarker.European archives of psychiatry and clinical neuroscience · 2025
    Article
  2. Article
  3. Article
  4. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  5. Review
  6. Review
  7. GαFrontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicolas B SeneseDepartments of Psychiatry and Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois, and Jesse Brown VA Medical Center, Chicago, Illinois.
Mark M RasenickDepartments of Psychiatry and Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois, and Jesse Brown VA Medical Center, Chicago, Illinois raz@uic.edu.
Jesse Brown VA Medical Center · USUniversity of Illinois Chicago · US

Funding

Training in the Neuroscience of Mental HealthT32MH067631 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RASENICK, MARK M. · 2004 to 2024
$4.8M
Mechanism of Action for n-3 PUFA antidepressant propertiesR01AT009169 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RASENICK, MARK M. · 2015 to 2018
$1.5M
Lipid raft localization of Gs: a biomarker for depression and therapeutic responseI01BX001149 · VA · JESSE BROWN VA MEDICAL CENTER · PI RASENICK, MARK M. · 2012 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX004475 · VA · JESSE BROWN VA MEDICAL CENTER · PI MARK M. RASENICK · 2019 to 2026
–
BLRD VA I01 BX001149BLRD VA IK6 BX004475NCCIH NIH HHS R01 AT009169NIMH NIH HHS T32 MH067631
6 · The paper itself

Abstract

Termination of antidepressant therapy often has negative consequences. Although symptoms of antidepressant withdrawal are widely recognized, the molecular processes that underlie them are not well characterized. We show that certain aspects of G

Indexed as

AnimalsAntidepressive AgentsCell LineGene Expression RegulationGTP-Binding Protein alpha Subunits, GsHEK293 CellsHumansMembrane MicrodomainsRatsSignal TransductionAntidepressive AgentsGTP-Binding Protein alpha Subunits, Gs

Identifiers

PMID34011569
PMCPMC8382257
OpenAlexW3159998421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.