Evidence map›Paper›PMID 34011540›Full record

ArticleJournal of virology2021

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

Jérémy A Ferreira Barbosa, Samantha Sparapani, Jonathan Boulais, Robert Lodge, Éric A Cohen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jérémy A Ferreira BarbosaMontreal Clinical Research Institute, Montréal, Québec, Canada.
Samantha SparapaniMontreal Clinical Research Institute, Montréal, Québec, Canada.
Jonathan BoulaisMontreal Clinical Research Institute, Montréal, Québec, Canada.
Robert LodgeMontreal Clinical Research Institute, Montréal, Québec, Canada.
Éric A CohenMontreal Clinical Research Institute, Montréal, Québec, Canada.
Montreal Clinical Research Institute · CA

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (CIHR) HB2-164064
6 · The paper itself

Abstract

HIV-1 encodes several accessory proteins-Nef, Vif, Vpr, and Vpu-whose functions are to modulate the cellular environment to favor immune evasion and viral replication. While Vpr was shown to mediate a G

Indexed as

Apc1 Subunit, Anaphase-Promoting Complex-CyclosomeCD4-Positive T-LymphocytesCell Line, TumorG2 Phase Cell Cycle CheckpointsHEK293 CellsHeLa CellsHIV-1HIV InfectionsHumansMacrophagesProtein Serine-Threonine KinasesRNA InterferenceRNA, Small InterferingTandem Mass SpectrometryUbiquitin-Protein LigasesVirus ReplicationANAPC1 protein, humanApc1 Subunit, Anaphase-Promoting Complex-CyclosomeDCAF1 protein, humanProtein Serine-Threonine KinasesRNA, Small InterferingUbiquitin-Protein Ligasesvpr Gene Products, Human Immunodeficiency Virusanaphase-promoting complex/cyclosomeAPC1BioIDcell cycle regulationHIV infectionhuman immunodeficiency virusproteomicsproximity labelingVpr

Identifiers

PMID34011540
PMCPMC8274603
OpenAlexW3161360412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.