Evidence map›Paper›PMID 34011522›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Th17 Cells Contribute to the Pathology of Autoimmune Hypophysitis.

Paulina Chalan, Nithya Thomas, Patrizio Caturegli

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Immune-Mediated Hypophysitis: An Updated Review.Journal of clinical medicine · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.The Journal of clinical endocrinology and metabolism · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paulina ChalanDivision of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD.
Nithya ThomasDivision of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD.
Patrizio CaturegliDivision of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD pcat@jhmi.edu.ORCID 0000-0001-6768-6308
Johns Hopkins University · US

Funding

Improving Diagnosis and Management of Cancer Immunotherapy-Induced HypophysitisR01CA194042 · NCI · JOHNS HOPKINS UNIVERSITY · PI CATUREGLI, PATRIZIO · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA194042
6 · The paper itself

Abstract

Autoimmune hypophysitis is classified as primary if its origin is idiopathic and secondary if it develops as a consequence of treatment with immune checkpoint inhibitors. Expanding use of immunotherapy has been paralleled by the increasing hypophysitis prevalence. However, understanding of the immune responses driving the disease remains limited. Using a mouse model of primary hypophysitis, we have identified CD4

Indexed as

AnimalsAutoimmune HypophysitisFemaleMiceMice, Inbred StrainsTh17 Cells

Identifiers

PMID34011522
PMCPMC9245460
OpenAlexW3161020409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.