Evidence map›Paper›PMID 34011519›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

The Roles of Type 2 Cytotoxic T Cells in Inflammation, Tissue Remodeling, and Prostaglandin (PG) D

Wentao Chen, Jian Luo, Yuan Ye, Ryan Hoyle, Wei Liu, Rowie Borst, Shamsah Kazani, Eric A Shikatani, Veit J Erpenbeck, Ian D Pavord and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. The PGDCommunications biology · 2026
    Article
  2. Review
  3. Article
  4. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  5. Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  6. Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. T-cell responses in asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Wentao ChenRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Jian LuoRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Yuan YeRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6541-0332
Ryan HoyleRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9084-962X
Wei LiuRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1811-9520
Rowie BorstRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2165-9894
Shamsah KazaniNovartis Institutes for BioMedical Research, Cambridge MA.ORCID 0000-0002-1234-8253
Eric A ShikataniNovartis Institutes for BioMedical Research, Cambridge MA.
Veit J ErpenbeckNovartis Pharma, AG, Basel, Switzerland; and.
Ian D PavordRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4288-5973
Paul KlenermanTranslational Gastroenterology Unit and Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.
David A SandhamNovartis Institutes for BioMedical Research, Cambridge MA.
Luzheng XueRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; luzheng.xue@ndm.ox.ac.uk.ORCID 0000-0003-0042-1262
National Institute for Health Research · GBNovartis (United States) · USNovartis (Switzerland) · CHUniversity of Oxford · GB

Funding

Wellcome Trust 109965Wellcome Trust 109965/Z/15/Z
6 · The paper itself

Abstract

Human type 2 cytotoxic T (Tc2) cells are enriched in severe eosinophilic asthma and can contribute to airway eosinophilia. PGD

Indexed as

Cells, CulturedCoculture TechniquesHumansIndoleacetic AcidsInflammationProstaglandin D2PyridinesReceptors, ImmunologicReceptors, ProstaglandinT-Lymphocytes, CytotoxicfevipiprantIndoleacetic AcidsProstaglandin D2prostaglandin D2 receptorPyridinesReceptors, ImmunologicReceptors, Prostaglandin

Identifiers

PMID34011519
PMCPMC7610864
OpenAlexW3163603027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.