ReviewBMJ global health2021
Vaccine safety issues at the turn of the 21st century.
Review in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Takotsubo syndrome and vaccines: a systematic review.ESC heart failure · 2024Pooled it
- Understanding adverse events following immunisation: evidence of vaccine safety and coincidental events from 3 years of surveillance.BMJ paediatrics open · 2026Article
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Perceptions of Vaccination in Latin America: Insights from Panama, the Dominican Republic, and Guatemala.Cureus · 2026Article
- Preclinical study on an adsorbed acellular diphtheria- tetanus-pertussis (reduced-dose) combined vaccine: evaluation of reproductive safety and immunogenicity.Frontiers in immunology · 2026Article
- COVID-19 vaccine compliance among pregnant women in Poland during the pandemic.Frontiers in public health · 2026Article
- Surveillance and analysis of adverse events following immunization (AEFI) with measles, mumps, and rubella (MMR) vaccine in Zhejiang Province, China, 2020-2025.Frontiers in public health · 2026Article
- Article
- Systematic annotation and analysis of susceptibility genes associated with vaccine adverse events.BMC medical genomics · 2025Article
- Establishing a Multicenter Active Adverse Events Following Immunization Sentinel Surveillance Network Across 22 Tertiary Care Hospitals in India: Protocol for a Prospective Observational Study.JMIR research protocols · 2025Article
- Impact of Covid-19 Pandemic on Knowledge and Attitude of Nursing Students Regarding Vaccination and Vaccine Hesitancy in China: A Cross-Sectional Study.Health science reports · 2025Article
- Developmental Disturbances in Animal Models of Autism Spectrum Disorder.Developmental neurobiology · 2025Review
- Role of Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock Secondary to Takotsubo Syndrome: A Case Series.International journal of women's health · 2025Article
- Global burden of diphtheria, 1990-2021: a 204-country analysis of socioeconomic inequality based on SDI and DTP3 vaccination differences before and after the COVID-19 pandemic (GBD 2021).Frontiers in public health · 2025Article
- Knowledge and reporting of adverse events following childhood immunization (AEFI) among health workers and caregivers at Mengo Hospital (2021), Kampala, Uganda: A mixed-methods study.PLOS global public health · 2025Article
- Vaccine Efficacy and Safety in Patients with Celiac Disease.Vaccines · 2024Review
- Article
- Article
- Assessing the Impact of the COVID-19 Pandemic on Pregnant Women's Attitudes towards Childhood Vaccinations: A Cross-Sectional Study.Vaccines · 2024Article
- How has research on the effectiveness and safety of COVID-19 vaccination been evaluated: a scope review with emphasis on CoronaVac.Frontiers in public health · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Global gains in vaccination coverage during the early 21st century have been threatened by the emergence of antivaccination groups that have questioned the effectiveness of vaccines to generate public distrust of vaccines and immunisation programmes. This manuscript summarises six key topics that have been at the centre of global discussions on vaccine safety during the early 21st century: thiomersal in multi-dose non-live vaccines, aluminium adjuvants used with several non-live vaccines, autism and auto-immune conditions as possible consequences of vaccination, a risk of immune overload with increasing numbers of vaccinations, and detrimental non-specific effects (NSEs) of vaccination. For each topic, we describe the hypothesis behind the public concern, the evidence reviewed by the WHO's Global Advisory Committee for Vaccine Safety (GACVS) during 1999-2019, and any significant new data that has emerged since GACVS conclusions were made. Although the scientific evidence on these issues overwhelmingly supports the safety of vaccines, communication messages to caregivers and providers need to condense and convey scientific information in an appropriate way to address concerns contributing to vaccine distrust. In addition, there is need for further studies specifically designed to address both positive and negative NSE of vaccination. The role of GACVS will be increasingly important in evaluating the evidence and engaging the global community in promoting and assuring the safety of vaccines in the decades to come as we move into an era in which we use new vaccination platforms, antigens and formulations.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.