ArticleeLife2021
Standardized and reproducible measurement of decision-making in mice.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 140 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022Pooled it
- Large cranial windows distort auditory cortical maps and degrade feature integration in secondary auditory cortex.iScience · 2026Article
- Standardizing deoxygenation studies in coral biology.Communications biology · 2026Review
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
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- Learning induces activation-mechanism-dependent neural plasticity in an intracortical microstimulation task.Science advances · 2026Article
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice.iScience · 2026Article
- Article
- Toward video-LLM driven workflow for behavioral segmentation and scoring in mice performing a skilled water-reaching task: an evaluation of recent LLM models.Neurophotonics · 2026Article
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- Article
- EthoPy provides an accessible platform for reproducible behavioral neuroscience.Cell reports methods · 2026Article
- Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- A shared multi-feature population code for sensory reliability across mouse visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in exploration-exploitation strategies during home-cage decision making.bioRxiv : the preprint server for biology · 2026Article
- Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.Neuroscience · 2026Article
- The neural code of perceptual inference.Molecular brain · 2026Review
80 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
38 authors.
Funding
Abstract
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements of mouse behavior. Here, we show that a standardized task to probe decision-making in mice produces reproducible results across multiple laboratories. We adopted a task for head-fixed mice that assays perceptual and value-based decision making, and we standardized training protocol and experimental hardware, software, and procedures. We trained 140 mice across seven laboratories in three countries, and we collected 5 million mouse choices into a publicly available database. Learning speed was variable across mice and laboratories, but once training was complete there were no significant differences in behavior across laboratories. Mice in different laboratories adopted similar reliance on visual stimuli, on past successes and failures, and on estimates of stimulus prior probability to guide their choices. These results reveal that a complex mouse behavior can be reproduced across multiple laboratories. They establish a standard for reproducible rodent behavior, and provide an unprecedented dataset and open-access tools to study decision-making in mice. More generally, they indicate a path toward achieving reproducibility in neuroscience through collaborative open-science approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.