Evidence map›Paper›PMID 34011372›Full record

SynthesisJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021

Four-dimensional flow cardiovascular magnetic resonance in tetralogy of Fallot: a systematic review.

Ayah Elsayed, Kathleen Gilbert, Miriam Scadeng, Brett R Cowan, Kuberan Pushparajah, Alistair A Young

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Society for Cardiovascular Magnetic Resonance 2022 Cases of SCMR case series.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  18. Review
  19. 2021-2022 state of our JCMR.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  20. Impact of ferumoxytol vs gadolinium on 4D flow cardiovascular magnetic resonance measurements in small children with congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayah ElsayedDepartment of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
Kathleen GilbertAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Miriam ScadengDepartment of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
Brett R CowanInstitute of Environmental Science and Research, Auckland, New Zealand.
Kuberan PushparajahDepartment of Biomedical Engineering, King's College London, London, UK.
Alistair A YoungDepartment of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. Alistair.Young@kcl.ac.uk.ORCID 0000-0001-5702-4220

Funding

The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023
$5.0M
NHLBI NIH HHS R01 HL121754
6 · The paper itself

Abstract

backgroundPatients with repaired Tetralogy of Fallot (rTOF) often develop cardiovascular dysfunction and require regular imaging to evaluate deterioration and time interventions such as pulmonary valve replacement. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) enables detailed assessment of flow characteristics in all chambers and great vessels. We performed a systematic review of intra-cardiac 4D flow applications in rTOF patients, to examine clinical utility and highlight optimal methods for evaluating rTOF patients.

methodsA comprehensive literature search was undertaken in March 2020 on Google Scholar and Scopus. A modified version of the Critical Appraisal Skills Programme (CASP) tool was used to assess and score the applicability of each study. Important clinical outcomes were assessed including similarities and differences.

resultsOf the 635 articles identified, 26 studies met eligibility for systematic review. None of these were below 59% applicability on the modified CASP score. Studies could be broadly classified into four groups: (i) pilot studies, (ii) development of new acquisition methods, (iii) validation and (vi) identification of novel flow features. Quantitative comparison with other modalities included 2D phase contrast CMR (13 studies) and echocardiography (4 studies). The 4D flow study applications included stroke volume (18/26;69%), regurgitant fraction (16/26;62%), relative branch pulmonary artery flow(4/26;15%), systolic peak velocity (9/26;35%), systemic/pulmonary total flow ratio (6/26;23%), end diastolic and end systolic volume (5/26;19%), kinetic energy (5/26;19%) and vorticity (2/26;8%).

conclusions4D flow CMR shows potential in rTOF assessment, particularly in retrospective valve tracking for flow evaluation, velocity profiling, intra-cardiac kinetic energy quantification, and vortex visualization. Protocols should be targeted to pathology. Prospective, randomized, multi-centered studies are required to validate these new characteristics and establish their clinical use.

Indexed as

Tetralogy of FallotHeart VentriclesHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPredictive Value of TestsProspective StudiesRetrospective Studies4D flowCardiovascular magnetic resonanceTetralogy of Fallot

Identifiers

PMID34011372
PMCPMC8136126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.