Evidence map›Paper›PMID 34011352›Full record

ArticleOrphanet journal of rare diseases2021

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans.

Christian Schwarm, Damian Gola, Maike M Holtsche, Anabelle Dieterich, Anita Bhandari, Miriam Freitag, Peter Nürnberg, Mohammad Toliat, Wolfgang Lieb, Michael Wittig and 25 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 12 institutions in 3 countries.

Christian SchwarmLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Damian GolaCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Maike M HoltscheDepartment of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Anabelle DieterichDepartment of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Anita BhandariCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Miriam FreitagLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Peter NürnbergCologne Center for Genomics, University of Cologne, Cologne, Germany.
Mohammad ToliatCologne Center for Genomics, University of Cologne, Cologne, Germany.
Wolfgang LiebInstitute of Epidemiology and Popgen Biobank, Christian Albrechts-University of Kiel, Kiel, Germany.
Michael WittigInstitute of Clinical Molecular Biology, Christian Albrechts-University of Kiel, Kiel, Germany.
André FrankeInstitute of Clinical Molecular Biology, Christian Albrechts-University of Kiel, Kiel, Germany.
Margitta WormAllegologie Und Immunologie, Klinik Für Dermatologie, Venerologie und Allergologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Michael SticherlingDepartment of Dermatology, University Hospital Erlangen, Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
Jan EhrchenDepartment of Dermatology, University of Münster, Münster, Germany.
Claudia GüntherDepartment of Dermatology, University Hospital Dresden, Dresden, Germany.
Regine GläserUniversity Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Wiebke K PeitschDepartment of Dermatology and Phlebology, Vivantes Klinikum Im Friedrichshain, Berlin, Germany.
Miklós SárdyDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Rüdiger EmingDepartment of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany.
Michael HertlDepartment of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany.
Sandrine BenoitDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Matthias GoebelerDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Claudia PföhlerDepartment of Dermatology, Saarland University Medical Center, Homburg/Saar, Germany.
Manfred KunzDepartment of Dermatology, Venereology and Allergology, Leipzig University Medical Center, Leipzig, Germany.
Alexander KreuterDepartment of Dermatology, Venerology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University Witten/Herdecke, Oberhausen, Germany.
Nina van BeekCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Jeanette ErdmannCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Hauke BuschLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Detlef ZillikensCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Christian D SadikCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Misa HiroseLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Inke R KönigCRIS, Center for Research On Inflammation of the Skin, University of Lübeck, Lübeck, Germany.
Enno Schmidt *Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Saleh M Ibrahim *Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. saleh.ibrahim@uksh.de.
German AIBD Study Group
University Hospital Schleswig-Holstein · DEUniversity of Lübeck · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Cologne · DEPhilipps University of Marburg · DESemmelweis University · HUUniversitätsklinikum Würzburg · DEUniversity of Münster · DEUniversity of Sharjah · AEHELIOS St. Elisabeth Klinik Oberhausen · DESaarland University · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the first genome-wide association study (GWAS) in Germans. This GWAS was combined with HLA locus targeted sequencing in an additional independent BP cohort. The strongest association with BP in Germans tested in this study was observed in the two HLA loci, HLA-DQA1*05:05 and HLA-DRB1*07:01. Further studies with increased sample sizes and complex studies integrating multiple pathogenic drivers will be conducted.

Indexed as

Pemphigoid, BullousAllelesAutoantibodiesAutoantigensGenome-Wide Association StudyGermanyHLA-DQ alpha-ChainsHLA-DRB1 ChainsHumansNon-Fibrillar CollagensAutoantibodiesAutoantigensHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DRB1 ChainsNon-Fibrillar CollagensAutoimmune blistering skin diseasesBullous pemphigoidGermansGWASHLA

Identifiers

PMID34011352
PMCPMC8136166
OpenAlexW3163106722

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.