Evidence map›Paper›PMID 34011305›Full record

ArticleBMC pediatrics2021

Reference intervals for hemoglobin and mean corpuscular volume in an ethnically diverse community sample of Canadian children 2 to 36 months.

Jemila S Hamid, Eshetu G Atenafu, Cornelia M Borkhoff, Catherine S Birken, Jonathon L Maguire, Mary Kathryn Bohn, Khosrow Adeli, Mohamed Abdelhaleem, Patricia C Parkin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01869530 (TARGet Kids!), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01869530 recruitingnot on this map

TARGet Kids!: Measuring Nutrition in Young Preschool Children in the Primary Care Practice Setting

Typeobservational_patient_registrySponsorThe Hospital for Sick ChildrenRan2008 to 2030Enrolled14,000ConditionsNutritional Disorders, Obesity, Development
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Advances in laboratory medicine · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jemila S HamidDepartment of Mathematics and Statistics, University of Ottawa, Ottawa, Canada.
Eshetu G AtenafuBiostatistics Department, Princess Margaret Cancer Center, University Health Network, Toronto, Canada.
Cornelia M BorkhoffPediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada.
Catherine S BirkenPediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada.
Jonathon L MaguirePediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada.
Mary Kathryn BohnCALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.
Khosrow AdeliCALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.
Mohamed AbdelhaleemDepartment of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada.
Patricia C ParkinPediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada. patricia.parkin@sickkids.ca.
University of Toronto · CAHospital for Sick Children · CASt. Michael's Hospital · CAUniversity Health Network · CAUniversity of Ottawa · CA

Funding

CIHR FRN 115059
6 · The paper itself

Abstract

objectiveTo establish reference intervals for hemoglobin and mean corpuscular volume (MCV) in an ethnically diverse community sample of Canadian children 36 months and younger.

methodsWe collected blood samples from young children at scheduled primary care health supervision visits at 2 weeks, 2, 4, 6, 9, 12, 15, 18, 24, and 36 months of age. Samples were analyzed on the Sysmex XN-9000 Hematology Analyzer. We followed the Clinical and Laboratory Standards Institute guidelines in our analysis. Data were partitioned by sex and also combined. We considered large age partitions (3 and 6 months) as well as monthly partitions. Reference intervals (lower and upper limits) and 90% confidence intervals were calculated.

resultsData from 2106 children were included. The age range was 2 weeks to 36 months, 46% were female, 48% were European and 23% were of mixed ethnicity. For hemoglobin, from 2 to 36 months of age, we found a wide reference interval and the 90% confidence intervals indicated little difference across age groups or according to sex. For MCV, from 2 to 7 months of age there was considerable decrease in the reference interval, which was lowest during the second year of life, followed by a slight increase in the last months of the third year of life.

conclusionThese findings suggest adoption of a single hemoglobin reference interval for children 2-36 months of age. Further studies in children under 4 months of age are needed.

trial registrationTARGet Kids! cohort is registered at ClinicalTrials.gov. www.clinicaltrials.gov . Identifier: NCT01869530 .

Indexed as

Erythrocyte IndicesHemoglobinsCanadaChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleReference StandardsReference ValuesHemoglobinsHemoglobinMean corpuscular volumeReference intervals

Identifiers

PMID34011305
PMCPMC8132375
OpenAlexW3162980671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.