Evidence map›Paper›PMID 34011136›Full record

ArticleHaematologica2021

Non-inhibitory antibodies inducing increased emicizumab clearance in a severe haemophilia A inhibitor patient.

Annie Harroche, Thibaud Sefiane, Maximilien Desvages, Delphine Borgel, Dominique Lasne, Caterina Casari, Ivan Peyron, Laurent Frenzel, Stéphanie Chhun, Peter J Lenting and 1 more

Abstract read
In one paragraph

Article in Haematologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Anti-emicizumab antibodies and their relevance in clinical practice.Research and practice in thrombosis and haemostasis · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Measuring Emicizumab Levels in the Hemostasis Laboratory.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Emicizumab state-of-the-art update.Haemophilia : the official journal of the World Federation of Hemophilia · 2022
    Article
  7. Article
  8. Factor-mimetic and rebalancing therapies in hemophilia A and B: the end of factor concentrates?Hematology. American Society of Hematology. Education Program · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Annie HarrocheCentre de Traitement de l'Hémophilie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Thibaud SefianeLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre.
Maximilien DesvagesLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France; Laboratoire d'hématologie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Delphine BorgelLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France; Laboratoire d'hématologie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Dominique LasneLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France; Laboratoire d'hématologie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Caterina CasariLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre.
Ivan PeyronLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre.
Laurent FrenzelCentre de Traitement de l'Hémophilie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Stéphanie ChhunLaboratoire d'immunologie biologique, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.
Peter J LentingLaboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixed de Recherche 1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, 94276 Le Kremlin-Bicêtre. peter.lenting@inserm.fr.
Cécile BallyCentre de Traitement de l'Hémophilie, AP-HP, Hôpital Necker Enfants Malades, 149, Rue de Sèvres, 75015 Paris.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, BispecificHemophilia AAntibodies, Monoclonal, HumanizedFactor VIIIHumansKineticsAntibodies, BispecificAntibodies, Monoclonal, HumanizedemicizumabFactor VIII

Identifiers

PMID34011136
PMCPMC8327735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.