Evidence map›Paper›PMID 34010956›Full record

ArticleAmerican journal of epidemiology2021

Influential Periods in Longitudinal Clinical Cardiovascular Health Scores.

Amy E Krefman, Darwin Labarthe, Philip Greenland, Lindsay Pool, Liliana Aguayo, Markus Juonala, Mika Kähönen, Terho Lehtimäki, R Sue Day, Lydia Bazzano and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05918744 (Sleep Extension and Vascular Health Study), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05918744 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Sleep Extension and Vascular Health Study

TypeinterventionalSponsorAuburn UniversityRan2023 to 2025Enrolled60ConditionsSleep, Vascular Diseases, Metabolic DiseaseArmsSleep Extension
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Associations of disordered eating and unhealthy weight control behaviors with cardiovascular health: The coronary artery risk development in young adults study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  11. Article
  12. Adherence to Pediatric Screening.Journal of the American Heart Association · 2024
    Article
  13. Article
  14. Article
  15. Lead exposure across the life course and age at death.The Science of the total environment · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Estimation of Life's Essential 8 Score with Incomplete Data of Individual Metrics.medRxiv : the preprint server for health sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Amy E Krefman
Darwin Labarthe
Philip Greenland
Lindsay Pool
Liliana Aguayo
Markus Juonala
Mika Kähönen
Terho Lehtimäki
R Sue Day
Lydia Bazzano
Vito M R Muggeo
Linda Van Horn
Lei Liu
Larry S Webber
Katja Pahkala
Tomi T Laitinen
Olli Raitakari
Donald M Lloyd-Jones
Norrina B Allen

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Childhood Secondhand Smoke and Longitudinal Cardiovascular Risk ProfileR01ES021724 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2012 to 2014
$1.8M
Dynamics and Health Consequences of Obesity between Infancy and Young Adulthood in the United StatesR01DK115937 · NIDDK · EMORY UNIVERSITY · PI ARGESEANU CUNNINGHAM, SOLVEIG · 2018 to 2021
$1.6M
PEDIATRIC EPIDEMIOLOGY OF CVD RISK FACTORSU01HL041166 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LABARTHE, DARWIN R. · 1990 to 1995
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NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS R01 HL121230NHLBI NIH HHS U01 HL041166NIA NIH HHS R01 AG016592NIDDK NIH HHS R01 DK115937NIEHS NIH HHS R01 ES021724NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

The prevalence of ideal cardiovascular health (CVH) among adults in the United States is low and decreases with age. Our objective was to identify specific age windows when the loss of CVH accelerates, to ascertain preventive opportunities for intervention. Data were pooled from 5 longitudinal cohorts (Project Heartbeat!, Cardiovascular Risk in Young Finns Study, The Bogalusa Heart Study, Coronary Artery Risk Development in Young Adults, Special Turku Coronary Risk Factor Intervention Project) from the United States and Finland from 1973 to 2012. Individuals with clinical CVH factors (i.e., body mass index, blood pressure, cholesterol, blood glucose) measured from ages 8 to 55 years were included. These factors were categorized and summed into a clinical CVH score ranging from 0 (worst) to 8 (best). Adjusted, segmented, linear mixed models were used to estimate the change in CVH over time. Among the 18,343 participants, 9,461 (52%) were female and 12,346 (67%) were White. The baseline mean (standard deviation) clinical CVH score was 6.9 (1.2) at an average age of 17.6 (8.1) years. Two inflection points were estimated: at 16.9 years (95% confidence interval: 16.4, 17.4) and at 37.2 years (95% confidence interval: 32.4, 41.9). Late adolescence and early middle age appear to be influential periods during which the loss of CVH accelerates.

Indexed as

Health BehaviorHeart Disease Risk FactorsAdolescentAdultAgedAge FactorsChildCohort StudiesFemaleHumansMaleMiddle AgedSex FactorsYoung Adultadolescencecardiovascular epidemiologycardiovascular healthcohort studieslongitudinal studiespreventionrisk factors

Identifiers

PMID34010956
PMCPMC8561125

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.