Evidence map›Paper›PMID 34010651›Full record

ArticleCell reports2021

Stability of the human gut virome and effect of gluten-free diet.

Sanzhima Garmaeva, Anastasia Gulyaeva, Trishla Sinha, Andrey N Shkoporov, Adam G Clooney, Stephen R Stockdale, Johanne E Spreckels, Thomas D S Sutton, Lorraine A Draper, Bas E Dutilh and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Viruses and celiac disease: what do we know ?Clinical and experimental medicine · 2023
    Pooled it
  2. Review
  3. Article
  4. Alternating High-Fat and Polysaccharide Diets Modulates Gut Phage-Bacterial Interplay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Gut virome dynamics: from commensal to critical player in health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Review
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  18. Article
  19. Phage diversity in One Health.Essays in biochemistry · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Sanzhima GarmaevaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Anastasia GulyaevaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Trishla SinhaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Andrey N ShkoporovAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Adam G ClooneyAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Stephen R StockdaleAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Johanne E SpreckelsDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Thomas D S SuttonAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Lorraine A DraperAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Bas E DutilhTheoretical Biology and Bioinformatics, Science for Life, Utrecht University, Utrecht 3584 CH, the Netherlands.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Alexander KurilshikovDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Jingyuan FuDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands.
Colin HillAPC Microbiome Ireland and School of Microbiology, University College Cork, Cork T12 YT20, Ireland.
Alexandra ZhernakovaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9713GZ, the Netherlands. Electronic address: a.zhernakova@umcg.nl.
University of Groningen · NLAPC Microbiome Institute · IEUniversity College Cork · IEUniversity Medical Center Groningen · NLUtrecht University · NL

Funding

Wellcome Trust 220646/Z/20/Z
6 · The paper itself

Abstract

The human gut microbiome consists of bacteria, archaea, eukaryotes, and viruses. The gut viruses are relatively underexplored. Here, we longitudinally analyzed the gut virome composition in 11 healthy adults: its stability, variation, and the effect of a gluten-free diet. Using viral enrichment and a de novo assembly-based approach, we demonstrate the quantitative dynamics of the gut virome, including dsDNA, ssDNA, dsRNA, and ssRNA viruses. We observe highly divergent individual viral communities, carrying on an average 2,143 viral genomes, 13.1% of which were present at all 3 time points. In contrast to previous reports, the Siphoviridae family dominates over Microviridae in studied individual viromes. We also show individual viromes to be stable at the family level but to vary substantially at the genera and species levels. Finally, we demonstrate that lower initial diversity of the human gut virome leads to a more pronounced effect of the dietary intervention on its composition.

Indexed as

Diet, Gluten-FreeGastrointestinal MicrobiomeHumansViromebacteriophagediversityecosystem resilienceglutengutmicrobiomeRNA virusesviral-like particlesvirome

Identifiers

PMID34010651
PMCPMC7619615
OpenAlexW3163659987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.