Evidence map›Paper›PMID 34010593›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2021

"D" matters in recombinant AAV DNA packaging.

Junping Zhang, Ping Guo, Yinxia Xu, Patrick L Mulcrone, R Jude Samulski, Weidong Xiao

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Reply to "D" matters in recombinant AAV packaging.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Junping ZhangHerman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA.
Ping GuoLewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Yinxia XuLewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Patrick L MulcroneHerman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA.
R Jude SamulskiDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: rjs@med.unc.edu.
Weidong XiaoHerman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA. Electronic address: xiaow@iu.edu.

Funding

Temple Project 1: Genetic characterization of factor VIII Inhibitors and glydosylation patternsU54HL142019 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MIAO, CAROL H · 2018 to 2022
$6.9M
Development of highly efficient factor VIII mini-gene therapyR01HL130871 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAO, WEIDONG · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL130871NHLBI NIH HHS U54 HL142019
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA, ViralGene Expression Regulation, ViralResponse ElementsDependovirusDNA, RecombinantGenetic EngineeringGenetic VectorsHumansTerminal Repeat SequencesVirus AssemblyVirus ReplicationDNA, RecombinantDNA, Viral

Identifiers

PMID34010593
PMCPMC8178517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.