ArticleJournal of neurophysiology2021
Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.
Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states.Cell reports · 2025Article
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Contrasting action and posture coding with hierarchical deep neural network models of proprioception.eLife · 2023Article
- Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex.Nature communications · 2023Article
- Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?Annual review of physiology · 2023Review
- Flexible intentions: An Active Inference theory.Frontiers in computational neuroscience · 2023Article
- Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
- Modulation of tactile feedback for the execution of dexterous movement.Science (New York, N.Y.) · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The cuneate nucleus (CN) is among the first sites along the neuraxis where proprioceptive signals can be integrated, transformed, and modulated. The objective of the study was to characterize the proprioceptive representations in CN. To this end, we recorded from single CN neurons in three monkeys during active reaching and passive limb perturbation. We found that many neurons exhibited responses that were tuned approximately sinusoidally to limb movement direction, as has been found for other sensorimotor neurons. The distribution of their preferred directions (PDs) was highly nonuniform and resembled that of muscle spindles within individual muscles, suggesting that CN neurons typically receive inputs from only a single muscle. We also found that the responses of proprioceptive CN neurons tended to be modestly amplified during active reaching movements compared to passive limb perturbations, in contrast to cutaneous CN neurons whose responses were not systematically different in the active and passive conditions. Somatosensory signals thus seem to be subject to a "spotlighting" of relevant sensory information rather than uniform suppression as has been suggested previously.
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