ArticleObstetrics & gynecology science2021
Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial.
Article in Obstetrics & gynecology science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Vitamin D for primary dysmenorrhea and endometriosis-related pain - A systematic review of registered RCTs.PloS one · 2025Pooled it
- Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials.Nutrients · 2024Pooled it
- The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review.Journal of medicine and life · 2023Pooled it
- Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Nutrients · 2023Pooled it
- Effects of vitamin D supplementation in endometriosis: a systematic review.Reproductive biology and endocrinology : RB&E · 2022Pooled it
- Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial.BMC women's health · 2025Trial
- The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial.BMC women's health · 2023Trial
- Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study.BMC complementary medicine and therapies · 2022Trial
- Curcumin, a bioactive supplement for premenstrual syndrome and dysmenorrhea: A systematic review of randomised clinical trials.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Complementary and alternative therapies in the treatment of primary dysmenorrhea.Frontiers in reproductive health · 2025Review
- Article
- The effect of vitamin D on adolescents' primary dysmenorrhea.Journal of medicine and life · 2023Article
- The impact of primary dysmenorrhea on adolescents' activities and school attendance.Journal of medicine and life · 2023Article
- The relation between primary dysmenorrhea in adolescents and body mass index.Przeglad menopauzalny = Menopause review · 2023Article
- High prevalence of hypovitaminosis D3 among pregnant women in central Iran: correlation with newborn vitamin D3 levels and negative association with gestational age.Obstetrics & gynecology science · 2023Article
- Vitamin D and vitamin D receptor polymorphism in Asian adolescents with primary dysmenorrhea.BMC women's health · 2023Article
- Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial.Obstetrics & gynecology science · 2023Article
- Severity of Menstrual Pain Is Associated with Nutritional Intake and Lifestyle Habits.Healthcare (Basel, Switzerland) · 2023Article
- Disease Burden of Dysmenorrhea: Impact on Life Course Potential.International journal of women's health · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent studies have shown a possible association between vitamin D deficiency and the severity of primary dysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemic symptoms in patients with primary dysmenorrhea.
methodsThis double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years with primary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IU of vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes were pain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), and severity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12).
resultsCompared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity (-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), the number of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 score at weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes.
conclusionVitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemic symptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.