Evidence map›Paper›PMID 34010527›Full record

ArticleThe New England journal of medicine2021

PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia.

Caroline Vayne, Jérôme Rollin, Yves Gruel, Claire Pouplard, Hubert Galinat, Olivier Huet, Vincent Mémier, Thomas Geeraerts, Raphael Marlu, Gilles Pernod and 4 more

Open access · bronzeAbstract readLetterComment
In one paragraph

Article in The New England journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. COVID-19 Vaccine-Associated Thrombosis With Thrombocytopenia Syndrome (TTS): A Systematic Review and Post Hoc Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  2. Thrombosis with Thrombocytopenia Syndrome After Administration of AZD1222 or Ad26.COV2.S Vaccine for COVID-19: A Systematic Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Pathogenic PF4/Polyvinylsulfonate ELISA-negative Antibodies in HIT.medRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Acute limb ischemia secondary to vaccine-induced thrombotic thrombocytopenia.Annals of vascular surgery. Brief reports and innovations · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Caroline VayneTours University Hospital, Tours, France gruel@med.univ-tours.fr.
Jérôme RollinTours University Hospital, Tours, France gruel@med.univ-tours.fr.
Yves GruelTours University Hospital, Tours, France gruel@med.univ-tours.fr.ORCID 0000-0002-1250-6063
Claire PouplardTours University Hospital, Tours, France gruel@med.univ-tours.fr.
Hubert GalinatBrest University Hospital, Brest, France.
Olivier HuetBrest University Hospital, Brest, France.
Vincent MémierToulouse University Hospital, Toulouse, France.ORCID 0000-0002-9912-2846
Thomas GeeraertsToulouse University Hospital, Toulouse, France.
Raphael MarluGrenoble Alpes University, Grenoble, France.
Gilles PernodGrenoble Alpes University, Grenoble, France.
Guillaume MoureyEtablissement Français du Sang, Besançon, France.
Alexandra FournelBesançon University Hospital, Besançon, France.
Charlotte CordonnierLille University Hospital, Lille, France.
Sophie SusenLille University Hospital, Lille, France.
Université de Tours · FRCentre Hospitalier Régional Universitaire de Brest · FRUniversité de Lille · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversité Grenoble Alpes · FRCentre Hospitalier Universitaire de Besançon · FRÉtablissement Français du Sang · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ThrombocytopeniaThrombosisVaccinesHeparinHumansImmunoassayHeparinVaccines

Identifiers

PMID34010527
PMCPMC8174029
OpenAlexW3161193856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.