Observational studyPloS one2021
Impact of obesity on outcome of severe bacterial infections.
Observational study in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Obesity and respiratory diseases: mechanisms, phenotypes, and clinical implications.Diabetology & metabolic syndrome · 2026Review
- Do Obesity Classifications Create the Obesity Paradox? A Scoping Review of Obesity Definitions Applied in Sepsis Research.Clinical obesity · 2026Article
- High BMI and low cardiorespiratory fitness in adolescence are associated with increased risk of severe bacterial infections in adulthood.Journal of internal medicine · 2026Article
- Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure.BMC cardiovascular disorders · 2025Article
- L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study.Diabetology & metabolic syndrome · 2025Article
- Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone.Antimicrobial agents and chemotherapy · 2024Article
- Impact of body mass index on mortality outcomes in intensive care patients with Staphylococcus aureus sepsis: A retrospective analysis.PloS one · 2024Article
- L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.Frontiers in medicine · 2024Article
- The causes of death in patients with nonalcoholic steatohepatitis following liver transplantation stratified using pre-liver transplant BMI.Hepatology international · 2023Article
- Does the "Obesity Paradox" Have an Expiration Date? A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- Implications of obesity and adiposopathy on respiratory infections; focus on emerging challenges.World journal of clinical cases · 2023Review
- Respiratory complications of obesity: from early changes to respiratory failure.Breathe (Sheffield, England) · 2023Review
- Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor.Frontiers in immunology · 2023Article
- Mean platelet volume is useful for predicting weaning failure: a retrospective, observational study.BMC anesthesiology · 2022Observational
- Elucidating the effect of body mass index, height, and parity on uncomplicated cystitis: a nationwide population-based cohort study.Scientific reports · 2022Article
- Association between Endocrine Disorders and Severe COVID-19 Disease in Pediatric Patients.Hormone research in paediatrics · 2022Article
- Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObesity is a rapidly growing global health concern with considerable negative impact on life-time expectancy. It has yet not been clarified if and how obesity impacts outcomes of severe bacterial infections. The aim of this study was to determine how body mass index impacts outcome of severe bacterial infections in a well-defined population-based cohort.
methodsThis study is based on a cohort of 2196 patients included in a Swedish prospective, population-based, consecutive observational study of the incidence of community-onset severe sepsis and septic shock in adults. All patients with weight and height documented in the medical records on admission were included.
resultsThe case fatality rate (CFR) was negatively correlating with increasing BMI. Outcomes included 28-day CFR (p-value = 0.002), hospital CFR (p-value = 0.039) and 1-year CFR (p-value<0.001). When BMI was applied as continuous variable in a multiple logistic regression together with other possible covariates, we still could discern that BMI was associated with decreasing 28-day CFR (OR = 0.93, 95% CI 0.88-0.98, p-value = 0.009) and 1-year CFR (OR = 0.94, 95% CI 0.91-0.97, p-value<0.001).
conclusionThe hypothesis and paradox of obesity being associated with higher survival rates in severe bacterial infections was confirmed in this prospective, population-based observational study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.