ArticlePLoS computational biology2021
Sensory modulation of gait characteristics in human locomotion: A neuromusculoskeletal modeling study.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026Review
- Simulating human foot mechanics during walking based on an anatomically detailed forward dynamic finite element model.Annals of biomedical engineering · 2026Article
- Modulating reflexes enables speed control in simulated human walking and running.Scientific reports · 2026Article
- Validation of World Guideline gait speed and TUG cut-offs for fall risk stratification in ambulatory nursing home residents aged ≥ 80 years: a multicenter cross-sectional diagnostic study.BMC geriatrics · 2026Article
- Synergy Feedback Control Predicts Walking Across Multiple Cycles.bioRxiv : the preprint server for biology · 2026Article
- Synergy-based feedforward with minimal feedback control predicts walking over multiple cycles.Frontiers in bioengineering and biotechnology · 2026Article
- A spinal network of proprioceptive reflexes can produce a variety of bipedal gaits.Communications biology · 2025Article
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.Journal of neuroengineering and rehabilitation · 2025Article
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms of adaptive interlimb coordination to sudden ground loss: a neuromusculoskeletal modeling study.bioRxiv : the preprint server for biology · 2025Article
- A physiologically inspired hybrid CPG/Reflex controller for cycling simulations that generalizes to walking.PLoS computational biology · 2025Article
- A PRISMA systematic review through time on predictive musculoskeletal simulations.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- Article
- Discrepant Spatiotemporal Characteristics of Gait Impairments in Thalamic Infarction Patients.Brain and behavior · 2025Article
- Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025Review
- Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord.PLoS computational biology · 2025Article
- Controlling a simple model of bipedal walking to adapt to a wide range of target step lengths and step frequencies.PloS one · 2025Article
- Identifying essential factors for energy-efficient walking control across a wide range of velocities in reflex-based musculoskeletal systems.PLoS computational biology · 2024Article
- Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia.Journal of neuroengineering and rehabilitation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system of humans and other animals modulates spinal cord activity to achieve several locomotion behaviors. Previous neuromechanical models investigated the modulation of human gait changing selected parameters belonging to CPGs (Central Pattern Generators) feedforward oscillatory structures or to feedback reflex circuits. CPG-based models could replicate slow and fast walking by changing only the oscillation's properties. On the other hand, reflex-based models could achieve different behaviors through optimizations of large dimensional parameter spaces. However, they could not effectively identify individual key reflex parameters responsible for gait characteristics' modulation. This study investigates which reflex parameters modulate the gait characteristics through neuromechanical simulations. A recently developed reflex-based model is used to perform optimizations with different target behaviors on speed, step length, and step duration to analyze the correlation between reflex parameters and their influence on these gait characteristics. We identified nine key parameters that may affect the target speed ranging from slow to fast walking (0.48 and 1.71 m/s) as well as a large range of step lengths (0.43 and 0.88 m) and step duration (0.51, 0.98 s). The findings show that specific reflexes during stance significantly affect step length regulation, mainly given by positive force feedback of the ankle plantarflexors' group. On the other hand, stretch reflexes active during swing of iliopsoas and gluteus maximus regulate all the gait characteristics under analysis. Additionally, the results show that the hamstrings' group's stretch reflex during the landing phase is responsible for modulating the step length and step duration. Additional validation studies in simulations demonstrated that the modulation of identified reflexes is sufficient to regulate the investigated gait characteristics. Thus, this study provides an overview of possible reflexes involved in modulating speed, step length, and step duration of human gaits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.