ArticlePloS one2021
Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- A systematic review of functional near-infrared spectroscopy-based task paradigms in stroke rehabilitation.Frontiers in human neuroscience · 2025Pooled it
- Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.Ageing research reviews · 2023Pooled it
- Computer-aided cognitive training combined with tDCS can improve post-stroke cognitive impairment and cerebral vasomotor function: a randomized controlled trial.BMC neurology · 2024Trial
- Acute lack of sunlight exposure is associated with poorer cognitive test performance: evidence from two national cohorts in the United Kingdom.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- A novel neurovascular coupling analysis method based on simultaneous EEG-fNIRS for investigating the effects of working memory load.Medical & biological engineering & computing · 2026Article
- Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS.GeroScience · 2026Article
- Neural mechanisms of video learning influenced by pedagogical agents' image and voice: an fNIRS study.Frontiers in psychology · 2026Article
- Neurovascular coupling abnormalities in first-episode drug-naïve major depressive disorder patients.BMC psychiatry · 2025Article
- Exploring the relationship between prefrontal cortex activation, standing balance, and fatigue in people post-stroke: A fNIRS study.NeuroRehabilitation · 2025Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Muscle endurance, neuromuscular fatigability, and cognitive control during prolonged dual-task in people with chronic obstructive pulmonary disease: a case-control study.European journal of applied physiology · 2025Article
- The Crucial Role of the Blood-Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications.Journal of clinical medicine · 2025Review
- Spatial proximity effects on cognitive processing of multimedia learning among college students: evidence from functional near-infrared spectroscopy.Frontiers in psychology · 2025Article
- COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment.Biomolecules · 2024Article
- Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings.PNAS nexus · 2024Review
- Activities of the dorsolateral and medial prefrontal cortices during oral function training with cognitive training elements: a NIRS study.BMC oral health · 2024Article
- The effect of posture on the age dependence of neurovascular coupling.Physiological reports · 2024Article
- Prefrontal cortex oxygenation during a mentally fatiguing task in normoxia and hypoxia.Experimental brain research · 2024Article
- Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Understanding how the brain allocates resources to match the demands of active neurons under physiological conditions is critically important. Increased metabolic demands of active brain regions are matched with hemodynamic responses known as neurovascular coupling (NVC). Several methods that allow noninvasive assessment of brain activity in humans detect NVC and early detection of NVC impairment may serve as an early marker of cognitive impairment. Therefore, non-invasive NVC assessments may serve as a valuable tool to detect early signs of cognitive impairment and dementia. Working memory tasks are routinely employed in the evaluation of cognitive task-evoked NVC responses. However, recent attempts that utilized functional near-infrared spectroscopy (fNIRS) or transcranial Doppler sonography (TCD) while using a similar working memory paradigm did not provide convincing evidence for the correlation of the hemodynamic variables measured by these two methods. In the current study, we aimed to compare fNIRS and TCD in their performance of differentiating NVC responses evoked by different levels of working memory workload during the same working memory task used as cognitive stimulation. Fourteen healthy young individuals were recruited for this study and performed an n-back cognitive test during TCD and fNIRS monitoring. During TCD monitoring, the middle cerebral artery (MCA) flow was bilaterally increased during the task associated with greater cognitive effort. fNIRS also detected significantly increased activation during a more challenging task in the left dorsolateral prefrontal cortex (DLPFC), and in addition, widespread activation of the medial prefrontal cortex (mPFC) was also revealed. Robust changes in prefrontal cortex hemodynamics may explain the profound change in MCA blood flow during the same cognitive task. Overall, our data support our hypothesis that both TCD and fNIRS methods can discriminate NVC evoked by higher demand tasks compared to baseline or lower demand tasks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.