ArticleEndocrine connections2021
Thyroid hormone alterations in critically and non-critically ill patients with SARS-CoV-2 infection.
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review.Frontiers in endocrinology · 2024Pooled it
- Association of thyroid dysfunction and COVID-19: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- The Association Between COVID-19 and Thyroxine Levels: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- The endocannabinoid system in bovine tissues: characterization of transcript abundance in the growing Holstein steer.BMC veterinary research · 2024Article
- Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect.International journal of endocrinology and metabolism · 2024Article
- Thyroid dysfunction in COVID-19.Nature reviews. Endocrinology · 2024Review
- Clinical use of thyroglobulin: not only thyroid cancer.Endocrine · 2024Review
- A prospective study on endocrine function in patients with long-COVID symptoms.Hormones (Athens, Greece) · 2024Observational
- The relation between FTFrontiers in endocrinology · 2024Article
- Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China.Frontiers in endocrinology · 2024Article
- The prognostic utility of serum thyrotropin in hospitalized Covid-19 patients: statistical and machine learning approaches.Endocrine · 2023Article
- Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge.Life (Basel, Switzerland) · 2022Article
- Endocrine Aspects of ICU-Hospitalized COVID-19 Patients.Journal of personalized medicine · 2022Review
- The Potential of Thyroid Hormone Therapy in Severe COVID-19: Rationale and Preliminary Evidence.International journal of environmental research and public health · 2022Review
- Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship.International journal of environmental research and public health · 2022Review
- COVID-19 and thyroid disease: An infodemiological pilot study.World journal of methodology · 2022Article
- Hypothyroidism and Subclinical Hypothyroidism as a Consequence of COVID-19 Infection.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- COVID-19 and thyroid function: What do we know so far?Frontiers in endocrinology · 2022Review
- Patients With Autoimmune Thyroiditis Present Similar Immunological Response to COVID-19 BNT162b2 mRNA Vaccine With Healthy Subjects, While Vaccination May Affect Thyroid Function: A Clinical Study.Frontiers in endocrinology · 2022Article
- Thyroglobulin levels in COVID-19-positive patients: Correlations with thyroid function tests, inflammatory markers, and glucocorticoid use.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFollowing the evolution of COVID-19 pandemic, reports pointed on a high prevalence of thyroiditis-related thyrotoxicosis. Interpretation of thyroid tests during illness, however, is hampered by changes occurring in the context of non-thyroidal illness syndrome (NTIS). In order to elucidate these findings, we studied thyroid function in carefully selected cohorts of COVID-19 positive and negative patients.
designCohort observational study.
methodsWe measured TSH, FT4, T3 within 24 h of admission in 196 patients without thyroid disease and/or confounding medications. In this study, 102 patients were SARS-CoV-2 positive; 41 admitted in the ICU, 46 in the ward and 15 outpatients. Controls consisted of 94 SARS-CoV-2 negative patients; 39 in the ICU and 55 in the ward. We designated the thyroid hormone patterns as consistent with NTIS, thyrotoxicosis and hypothyroidism.
resultsA NTIS pattern was encountered in 60% of ICU and 36% of ward patients, with similar frequencies between SARS-CoV-2 positive and negative patients (46.0% vs 46.8%, P = NS). A thyrotoxicosis pattern was observed in 14.6% SARS-CoV-2 ICU patients vs 7.7% in ICU negative (P = NS) and, overall in 8.8% of SARS-CoV-2 positive vs 7.4% of negative patients. In these patients, thyroglobulin levels were similar to those with normal thyroid function or NTIS. The hypothyroidism pattern was rare.
conclusionsNTIS pattern is common and relates to the severity of disease rather than SARS-CoV-2 infection. A thyrotoxicosis pattern is less frequently observed with similar frequency between patients with and without COVID-19. It is suggested that thyroid hormone monitoring in COVID-19 should not differ from other critically ill patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.