Evidence map›Paper›PMID 34009667›Full record

ArticleJournal of the American Geriatrics Society2021

Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)-based retinal vascular imaging?

Alison G Abraham, Xinxing Guo, Lubaina T Arsiwala, Yanan Dong, A Richey Sharrett, David Huang, Qisheng You, Liang Liu, Brandon J Lujan, Alexander Tomlinson and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. OCTA: Essential or Gimmick?Ophthalmology and therapy · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Retinal Biomarkers for Alzheimer Disease: The Facts and the Future.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Alison G AbrahamDepartment of Epidemiology, University of Colorado, Anschutz Medical Campus, Denver, Colorado, USA.ORCID 0000-0002-6863-0565
Xinxing GuoWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lubaina T ArsiwalaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yanan DongDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
A Richey SharrettDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
David HuangCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Qisheng YouCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Liang LiuCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Brandon J LujanCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Alexander TomlinsonCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-6778-9590
Thomas MosleyThe MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Josef CoreshDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Yali JiaCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Aleksandra MihailovicWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Pradeep Y RamuluWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USOregon Health & Science University · USUniversity of Mississippi Medical Center · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
Optimizing Safety and Functionality in the Visually ImpairedR01EY022976 · NEI · JOHNS HOPKINS UNIVERSITY · PI RAMULU, PRADEEP YAMMANURU · 2013 to 2024
$5.2M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Understanding sex differences and the impact of image quality on OCT-derived measures of retinal microvascular health as surrogates of brain pathology for cognitive disease.R01AG052412 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABRAHAM, ALISON G, RAMULU, PRADEEP YAMMANURU · 2016 to 2019
$2.6M
NEI NIH HHS R01 EY022976NHLBI NIH HHS HHSN2682017NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01-HL70825NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS 1R01AG052412NIA NIH HHS R01 AG052412NIA NIH HHS R01AG052412NIH HHS 2U01HL096812NIH HHS 2U01HL096814NIH HHS 2U01HL096899NIH HHS 2U01HL096902NIH HHS 2U01HL096917
6 · The paper itself

Abstract

introductionAccumulated vascular damage contributes to the onset and progression of vascular dementia and possibly to Alzheimer's disease. Here we evaluate the feasibility and utility of using retinal imaging of microvascular markers to identify older adults at risk of cognitive disease.

methodsThe "Eye Determinants of Cognition" (EyeDOC) study recruited a biracial, population-based sample of participants from two sites: Jackson, MS, and Washington Co, MD. Optical coherence tomographic angiography (OCTA) was used to capture vessel density (VD) from a 6 × 6 mm scan of the macula in several vascular layers from 2017 to 2019. The foveal avascular zone (FAZ) area was also estimated. Image quality was assessed by trained graders at a reading center. A neurocognitive battery of 10 tests was administered at three time points from 2011 to 2019 and incident mild cognitive impairement (MCI)/dementia cases were ascertained. Linear mixed-effects models were used to evaluate associations of retinal vascular markers with cognitive factor score change over time.

resultsNine-hundred and seventy-six older adults (mean age of 78.7 (± 4.4) years, 44% black) were imaged. Gradable images were obtained in 55% (535/976), with low signal strength (66%) and motion artifact (22%) being the largest contributors to poor quality. Among the 297 participants with both high-quality images and no clinically significant retinal pathology, the average decline in global cognitive function factor score was -0.03 standard deviations per year. In adjusted analyses, no associations of VD or FAZ with longitudinal changes in either global cognitive function or with incident MCI/dementia were found.

conclusionsIn this large biracial community sample of older adults representative of the target population for retinal screening of cognitive risk, we found that obtaining high-quality OCTA scans was infeasible in a nearly half of older adults. Among the select sample of healthier older adults with scans, OCTA markers were not predictive of cognitive impairment.

Indexed as

Tomography, Optical CoherenceAgedAged, 80 and overAlzheimer DiseaseCognitive DysfunctionFemaleHumansMaleRetinal VesselsAlzheimer's diseasecognitive diseaseoptical coherence tomography angiography (OCTA)retinal markers

Identifiers

PMID34009667
PMCPMC8440348
OpenAlexW3160240308

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.