ArticleBiotechnology letters2021
High-cell-density fed-batch cultivations of Vibrio natriegens.
Article in Biotechnology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Is faster always better? A critical assessment of Vibrio natriegens as microbial host for recombinant protein production.Bioprocess and biosystems engineering · 2026Review
- Article
- High-cell-density cultivation of Vibrio natriegens N5.3 on chitin monomers: a step toward chitin valorization.Biotechnology letters · 2026Article
- Small-scale fed-batch cultivations of Vibrio natriegens: overcoming challenges for early process development.Bioprocess and biosystems engineering · 2025Article
- Vibrio natriegens: Application of a Fast-Growing Halophilic Bacterium.Advances in biochemical engineering/biotechnology · 2025Review
- A dual-inducible control system for multistep biosynthetic pathways.Journal of biological engineering · 2024Article
- Unraveling the impact of pH, sodium concentration, and medium osmolality on Vibrio natriegens in batch processes.BMC biotechnology · 2024Article
- High-cell-density cultivation of Vibrio natriegens in a low-chloride chemically defined medium.Applied microbiology and biotechnology · 2023Article
- Metabolic engineering of fast-growing Vibrio natriegens for efficient pyruvate production.Microbial cell factories · 2023Article
- Rapid, high-titer biosynthesis of melanin using the marine bacteriumFrontiers in bioengineering and biotechnology · 2023Article
- Biosensor-based isolation of amino acid-producingMetabolic engineering communications · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWith generation times of less than 10 min under optimal conditions, the halophilic Vibrio natriegens is the fastest growing non-pathogenic bacterium isolated so far. The availability of the full genome and genetic engineering tools and its ability to utilize a wide range of carbon sources make V. natriegens an attractive host for biotechnological production processes. However, high-cell-density cultivations, which are desired at industrial-scale have not been described so far.
resultsIn this study we report fed-batch cultivations of V. natriegens in deep-well plates and lab-scale bioreactor cultivations at different temperatures in mineral salt medium (MSM). Upon switching from exponential glucose to constant glucose-feeding cell death was induced. Initial NaCl concentrations of 15-18 g L
conclusionsThe shown fed-batch strategies demonstrate the potential of V. natriegens as a strong producer in industrial biotechnology.
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