Evidence map›Paper›PMID 34009526›Full record

ArticleAging clinical and experimental research2021

Association between frailty index, lung function, and major clinical determinants in chronic obstructive pulmonary disease.

Simone Scarlata, Panaiotis Finamore, Alice Laudisio, Vittorio Cardaci, Mattia Ramaccia, Francesco D'Alessandro, Claudio Pedone, Raffaele Antonelli Incalzi, Matteo Cesari

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In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  17. Frailty and Exacerbation of Chronic Obstructive Pulmonary Disease: Is There Any Association?International journal of chronic obstructive pulmonary disease · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Simone ScarlataInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy. scarlata.dott.simone@gmail.com.
Panaiotis FinamoreInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Alice LaudisioInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Vittorio CardaciPulmonary Rehabilitation Unit, IRCCS San Raffaele Pisana Scientific Institute, Rome, Italy.
Mattia RamacciaInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Francesco D'AlessandroInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Claudio PedoneInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Raffaele Antonelli IncalziInternal Medicine and Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University and Teaching Hospital, Via Alvaro del Portillo, 200, Rome, Italy.
Matteo CesariGeriatric Unit, Maugeri Clinical Research Institutes IRCCS, Milan, Italy.
Università Campus Bio-Medico · ITIstituti Clinici Scientifici Maugeri · ITIstituto di Ricovero e Cura a Carattere Scientifico San Raffaele

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAirflow limitation alone is unable to capture the complexity of chronic obstructive pulmonary disease (COPD), better explained by comprehensive disease-specific indexes. Frailty is a clinical condition characterized by high vulnerability to internal and external stressors and represents a strong predictor of adverse outcomes.

aimsPrimary objective was to test the association between indexes of lung function and COPD severity with frailty index (FI), and secondary to evaluate the association between FI and comorbidities, cognitive and physical function, BODE index, and mortality.

methods150 stable COPD outpatients were enrolled and followed up to 4 years. At baseline, participants performed a geriatric multidimensional assessment, pulmonary function tests, arterial blood gas analysis, 6-min walking test, and bioimpedance analysis. BODE and FI were calculated. Spearman's ρ was used to assess correlations. Mortality was assessed using Kaplan-Meier curves.

resultsParticipants were followed up for a median of 39 months. Mean age was 73 years and median frailty index 0.15 (IQR 0.11-0.19). FI was higher in frequent exacerbators (≥ 2/year) (mean 0.18 vs 0.15, p 0.01) and dyspnoeic patients (mMRC ≥ 2) (mean 0.21 vs 0.14, p < 0.01) and correlated with lung volumes, expiratory flows, and pressure of arterial oxygen. FI was positively correlated with the number of comorbidities, depressive symptoms, cognitive decline, and BODE index. Mortality was higher in patients with BODE higher than 3 (HR 3.6, 95% CI 1.2-10.9), and not associated with FI. DISCUSSION: FI positively correlates with all clinical drivers orienting the choice of treatment in COPD.

conclusionsFI associates with lung function and COPD severity, but does not associate with mortality.

Indexed as

FrailtyPulmonary Disease, Chronic ObstructiveAgedHumansLungRespiratory Function TestsSeverity of Illness IndexCOPDFrailtyOlderOutcomesPulmonary

Identifiers

PMID34009526
OpenAlexW3161306309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.