Evidence map›Paper›PMID 34009522›Full record

ReviewNeurosurgical review2022

Efficacy of antimicrobial medicated ventricular catheters: a network meta-analysis with trial sequential analysis.

Revanth Goda, Akshay Ganeshkumar, Varidh Katiyar, Ravi Sharma, Hitesh Kumar Gurjar, Aprajita Chaturvedi, Roshan Sahu, Hitesh Inder Singh Rai, Zainab Vora

Abstract readReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Review in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Revanth Goda *Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Akshay Ganeshkumar *Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Varidh KatiyarDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Ravi SharmaDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Hitesh Kumar GurjarDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India. hiteshgurjar@gmail.com.
Aprajita ChaturvediDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Roshan SahuDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Hitesh Inder Singh RaiDepartment of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Zainab VoraDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is paucity of evidence regarding relative performance of antibiotic-medicated (AM), silver-medicated (SM) and non-medicated (NM) ventricular catheters in controlling infection rate. We aim to quantitatively synthesize the current evidence after addition of the three-armed British Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts (BASICS) trial, understand the need for further evidence using trial sequential analysis (TSA) and incorporate the indirect evidence using network meta-analysis (NMA). Randomized controlled trials (RCTs) comparing AM, SM and NM ventriculoperitoneal shunt (VPS) or external ventricular drain (EVD) were included. Antibiotic-medicated VPS show a significantly lower infection rate as compared to non-medicated VPS (RR 0.44; 95% CI: 0.27-0.73; p = 0.001), however, TSA reveals need for further evidence. SM including both EVD as well as VPS were found to be inferior to AM while no significant difference was found in comparison to the NM catheters. In NMA for VPS, the AM were found to be significantly better than SM (RR 0.41, 95% CI: 0.22-0.75) as well as NM (RR 0.42; 95% CI: 0.25-0.71) with a SUCRA of 99.8% and a mean rank of 1. However, antibiotic medicated shunts did not show a statistically significant association with reoperation rate (RR 0.99; 95% CI:0.81-1.20; p = 0.9) with no further need for evidence as per TSA.

Indexed as

Anti-Infective AgentsCatheter-Related InfectionsAnti-Bacterial AgentsCathetersHumansAnti-Bacterial AgentsAnti-Infective AgentsAntibiotic-medicatedAntimicrobialExternal ventricular drainInfectionSilver-medicatedVentriculoperitoneal shunt

Identifiers

PMID34009522
OpenAlexW3163595475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.