Evidence map›Paper›PMID 34009445›Full record

ArticleSocial psychiatry and psychiatric epidemiology2022

The genetic background of the associations between sense of coherence and mental health, self-esteem and personality.

Karri Silventoinen, Eero Vuoksimaa, Salla-Maarit Volanen, Teemu Palviainen, Richard J Rose, Sakari Suominen, Jaakko Kaprio

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Karri SilventoinenFaculty of Social Sciences, Department of Social Research, University of Helsinki, P.O. Box 18, N00014, Helsinki, Finland. karri.silventoinen@helsinki.fi.ORCID http://orcid.org/0000-0003-1759-3079
Eero VuoksimaaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Salla-Maarit VolanenFolkhälsan Research Center, Helsinki, Finland.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Richard J RoseDepartment of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.
Sakari SuominenDepartment of Public Health, University of Turku, Turku, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIIndiana University Bloomington · USUniversity of Turku · FI

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
–
BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIESR01AA009203 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1994 to 1998
–
Academy of Finland 100499Academy of Finland 118555Academy of Finland 141054Academy of Finland 205585Academy of Finland 264146Academy of Finland 308248Academy of Finland 312073NIAAA NIH HHS AA-00145NIAAA NIH HHS AA-09203NIAAA NIH HHS AA-12502NIAAA NIH HHS AA15416NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502
6 · The paper itself

Abstract

purposeSense of coherence (SOC) represents coping and can be considered an essential component of mental health. SOC correlates with mental health and personality, but the background of these associations is poorly understood. We analyzed the role of genetic factors behind the associations of SOC with mental health, self-esteem and personality using genetic twin modeling and polygenic scores (PGS).

methodsInformation on SOC (13-item Orientation of Life Questionnaire), four mental health indicators, self-esteem and personality (NEO Five Factor Inventory Questionnaire) was collected from 1295 Finnish twins at 20-27 years of age.

resultsIn men and women, SOC correlated negatively with depression, alexithymia, schizotypal personality and overall mental health problems and positively with self-esteem. For personality factors, neuroticism was associated with weaker SOC and extraversion, agreeableness and conscientiousness with stronger SOC. All these psychological traits were influenced by genetic factors with heritability estimates ranging from 19 to 66%. Genetic and environmental factors explained these associations, but the genetic correlations were generally stronger. The PGS of major depressive disorder was associated with weaker, and the PGS of general risk tolerance with stronger SOC in men, whereas in women the PGS of subjective well-being was associated with stronger SOC and the PGSs of depression and neuroticism with weaker SOC.

conclusionOur results indicate that a substantial proportion of genetic variation in SOC is shared with mental health, self-esteem and personality indicators. This suggests that the correlations between these traits reflect a common neurobiological background rather than merely the influence of external stressors.

Indexed as

Major Depressive DisorderSense of CoherenceFemaleGenetic BackgroundHumansMaleMental HealthPersonalityPersonality InventoryMental healthPersonalityPolygenic scoreSense of coherenceTwins

Identifiers

PMID34009445
PMCPMC8602419
OpenAlexW3161952696

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.