Evidence map›Paper›PMID 34009397›Full record

ReviewRheumatology international2021

Rituximab for refractory eosinophilic fasciitis: a case series with long-term follow-up and literature review.

Nikolaos Kougkas, George Bertsias, Ioannis Papalopoulos, Argiro Repa, Prodromos Sidiropoulos, Nestor Avgoustidis

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Treatment and Monitoring of Eosinophilic Fasciitis.Current treatment options in rheumatology · 2025
    Article
  7. Article
  8. Recurrent Eosinophilic Fasciitis: The First Case Report.Clinical, cosmetic and investigational dermatology · 2025
    Article
  9. Is there a Role for Anti-IL-5 Therapies in Eosinophilic Fasciitis?Mediterranean journal of rheumatology · 2023
    Review
  10. [Eosinophilic dermatoses].Dermatologie (Heidelberg, Germany) · 2022
    Article
  11. Article
  12. Eosinophilic fasciitis: unraveling the clinical tapestry of a rare case and review of literature.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nikolaos KougkasDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece. nkougas@yahoo.gr.ORCID http://orcid.org/0000-0001-5275-8639
George BertsiasDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece.
Ioannis PapalopoulosDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece.
Argiro RepaDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece.
Prodromos SidiropoulosDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece.
Nestor AvgoustidisDepartment of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece.
University Hospital of Heraklion · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key messageRTX could be an effective and safe alternative treatment for refractory EF. Rituximab (RTX) is a successful therapeutic option for various autoimmune diseases. Our aim is to report our experience with RTX in eosinophilic fasciitis (EF) and review published data on its efficacy for the treatment of EF. We reviewed the medical charts of all patients with a diagnosis of EF treated with RTX from 2008 to 2020 in the Department of Rheumatology and Clinical Immunology in the University Hospital of Heraklion, Crete, Greece. We also reviewed the English literature for cases of EF treated with RTX. Demographics, clinical manifestations, laboratory findings, prior treatments, response to RTX, cumulative RTX dose, duration of treatment and follow-up are reported. We report three cases of EF refractory to conventional DMARDs (cDMARDs) that responded to RTX. Furthermore, literature review revealed five cases. In our case series in all patients, RTX was the first biologic. RTX could be effective in cases of (EF) refractory to standard immunosuppressive treatment.

Indexed as

AdultEosinophiliaFasciitisFemaleHumansImmunosuppressive AgentsMaleMiddle AgedRituximabTreatment OutcomeImmunosuppressive AgentsRituximabEosinophilic fasciitisRefractoryReviewRituximabTreatment

Identifiers

PMID34009397
OpenAlexW3160515934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.