ArticleToxicological sciences : an official journal of the Society of Toxicology2021
Firsthand and Secondhand Exposure Levels of Maltol-Flavored Electronic Nicotine Delivery System Vapors Disrupt Amino Acid Metabolism.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Metabolic disruption associated with e-cigarette vaping and secondhand exposure: Urinary metabolomics evidence from a Thai population.Toxicology reports · 2026Article
- Unveiling Oral Health Impacts of Vaping in African Americans through Untargeted Metabolomics and Proteomics.Environment & health (Washington, D.C.) · 2025Article
- Exploratory untargeted metabolomics analysis reveals differences in metabolite profiles in pregnant people exposed vs. unexposed to E-cigarettes secondhand in the NYU children's health and environment study.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Environmental basis for early onset breast cancer.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- The role of puff volume in vaping emissions, inhalation risks, and metabolic perturbations: a pilot study.Scientific reports · 2024Article
- Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide.Toxicology · 2024Article
- Article
- Prenatal Exposure to Tobacco and Cannabis in Six Race/Ethnicity Groups during the First Three Years after Legalization of Cannabis for Recreational Use in California.International journal of environmental research and public health · 2023Article
- Physical and chemical characterizations of a reference e-cigarette used in animal testing.Scientific reports · 2023Article
- Exposome epidemiology for suspect environmental chemical exposures during pregnancy linked to subsequent breast cancer diagnosis.Environment international · 2023Article
- Low-dose vanadium pentoxide perturbed lung metabolism associated with inflammation and fibrosis signaling in male animal and in vitro models.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Metabolomics of VToxicology and applied pharmacology · 2023Article
- Laboratory Determination of Gravimetric Correction Factors for Real-time Area Measurements of Electronic Cigarette Aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Electronic nicotine delivery system (ENDS) use has become a popular, generally regarded as safe, alternative to tobacco use. The e-liquids used for ENDS vapor generation commonly contain flavoring agents, such as maltol, which have been subjected to little investigation of their effects on lung health from ENDS usage. In the present study, we examined the impacts of firsthand (3.9 mM) and secondhand (3.9 µM) exposure levels to maltol-flavored ENDS vapors on lung metabolism. Human lung bronchial epithelial cells were exposed to ENDS vapors using a robotic system for controlled generation and delivery of exposures, and the effects on metabolism were evaluated using high-resolution metabolomics. The results show that maltol in e-liquids impacts lung airway epithelial cell metabolism at both firsthand and secondhand exposure levels. The effects of maltol were most notably seen in amino acid metabolism while oxidative stress was observed with exposure to all ENDS vapors including e-liquids alone and maltol-contained e-liquids. Many effects of firsthand exposure were also observed with secondhand exposure, suggesting need for systematic investigation of both firsthand and secondhand effects of flavored ENDS vapors on lung metabolism and risk of lung disease.
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Registered trials
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