Evidence map›Paper›PMID 34009327›Full record

ArticleBrain : a journal of neurology2021

Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy.

Elizabeth S Silagi, Rosalind A Segal

Open access · bronzeAbstract readComment
In one paragraph

Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth S SilagiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Rosalind A SegalDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-9850-8432
Harvard University · US

Funding

Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
(PQ9) The role of Bclw (bcl2l2) in preventing chemotherapy induced neuropathyR01CA205255 · NCI · DANA-FARBER CANCER INST · PI ROSALIND ANNE SEGAL · 2016 to 2026
$5.8M
NCI NIH HHS R01 CA205255NIA NIH HHS T32 AG000222NICHD NIH HHS P50 HD105351NIH HHS R01-NS050674
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Agents, PhytogenicPeripheral Nervous System DiseasesHumansPaclitaxelAntineoplastic Agents, PhytogenicPaclitaxel

Identifiers

PMID34009327
PMCPMC8320290
OpenAlexW3160748238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.