Evidence map›Paper›PMID 34009318›Full record

ArticleSchizophrenia bulletin2021

The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study.

Baptiste Pignon, Mohamed Lajnef, James B Kirkbride, Hugo Peyre, Aziz Ferchiou, Jean-Romain Richard, Grégoire Baudin, Sarah Tosato, Hannah Jongsma, Lieuwe de Haan and 26 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. The Relationship Between Trauma Exposure and Nonclinical Psychosis: A Systematic Review and Meta-Analysis.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Stress, Environment and Early Psychosis.Current neuropharmacology · 2024
    Review
  12. Review
  13. Urbanicity and psychotic disorders: Facts and hypotheses.Dialogues in clinical neuroscience · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 7 countries.

Baptiste PignonUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.ORCID 0000-0003-0526-3136
Mohamed LajnefUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
James B KirkbridePsyLife group, Division of Psychiatry, UCL, London, UK.ORCID 0000-0003-3401-0824
Hugo PeyreAP-HP, Hôpital universitaire Robert Debré, Service de pédopsychiatrie, Paris, France.
Aziz FerchiouUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
Jean-Romain RichardUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
Grégoire BaudinUniversité de Paris, Laboratoire de Psychopathologie et Processus de Santé, Boulogne Billancourt, France.
Sarah TosatoSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Hannah JongsmaCentre for Transcultural Psychiatry "Veldzicht." Balkbrug, the Netherlands; VR Mental Health Group, University Center for Psychiatry, Univerisity Medical Centre Groningen, Groningen, The Netherlands.
Lieuwe de HaanAmsterdam UMC, Amsterdam, The Netherlands.
Ilaria TarriconeDepartment of Medical and Surgical Sciences, Bologna University, Bologna, Italy.
Miguel BernardoBarcelona Clínic Schizophrenia Unit, Hospital Clínic of Barcelona, Institute of Neuroscience, University of Barcelona; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Eva VelthorstDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY.
Mauro BracaDepartment of Mental Health and Pathological Addictions, Local Health Authority, Bologna, Italy.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General.Universitario Gregorio Marañón, Gregorio Marañón, (IiGSM), School of Medicine, Universidad Complutense de Madrid; CIBERSAM, Madrid, Spain.
Manuel ArrojoDepartment of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Spain.
Julio BobesFaculty of Medicine and Health Sciences - Psychiatry, Universidad de Oviedo; ISPA, INEUROPA CIBERSAM, Oviedo, Spain.
Cristina Marta Del-BenDepartment of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Marta Di FortiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Charlotte Gayer-AndersonDepartment of Health Service and Population Research, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, UK.
Peter B JonesDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Caterina La CasciaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, School of Medicine, University of Palermo, Palermo, Italy.
Antonio LasalviaSection of Psychiatry, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Paulo Rossi MenezesDepartment of Preventive Medicine, Faculdade de Medicina, Universidade of São Paulo, São Paulo, Brazil.
Diego QuattroneSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Julio SanjuánBiomedical Research Networking Centre in Mental Health (CIBERSAM), Madrid, Spain.
Jean-Paul SeltenRivierduinen Institute for Mental Health, Leiden, The Netherlands.
Andrea TortelliFrench National Institute of Health and Medical Research (INSERM), Créteil, France.
Pierre-Michel LlorcaCHU Clermont-Ferrand, Psychiatrie B, Clermont-Ferrand, France.
Jim van OsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
Robin M MurrayThe Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Craig MorganDepartment of Health Service and Population Research, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, UK.
Marion LeboyerUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
Andrei SzökeUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
Franck SchürhoffUniv Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H. Mondor», DMU IMPACT, Fondation FondaMental, Créteil, France.
Inserm · FRKing's College London · GBUniversidade de São Paulo · BRUniversity of Verona · ITArkin · NLAssistance Publique – Hôpitaux de Paris · FRAzienda Unità Sanitaria Locale Della Romagna · ITCentro de Investigación Biomédica en Red de Salud Mental · ESComplejo Hospitalario Universitario de Santiago · ESIcahn School of Medicine at Mount Sinai · USMaastricht University · NLMaastricht University Medical Centre · NLUniversidad Complutense de Madrid · ESUniversidad de Oviedo · ESUniversitat de València · ESUniversité Clermont Auvergne · FRUniversité Paris Cité · FRUniversity College London · GBUniversity Medical Center Groningen · NLUniversity of Bologna · IT

Funding

Department of Health
6 · The paper itself

Abstract

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (β for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E × E interactions.

Indexed as

Social CapitalSocial EnvironmentAdultAdverse Childhood ExperiencesDepressionEuropean UnionFemaleHumansMalePsychotic DisordersSiblingsSocial DiscriminationStress, Psychologicalchildhood traumaCommunity Assessment of Psychic Experiences (CAPE)depressive subclinical symptomsdiscriminationnegative subclinical symptomspositive subclinical symptomspsychosocial stresspsychotic symptomsschizotypysocial capitalstressful life eventssubclinical psychosis

Identifiers

PMID34009318
PMCPMC8562561
OpenAlexW3162731805

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.