Evidence map›Paper›PMID 34009283›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2022

Dynamic nature of the LVOT following transcatheter mitral valve replacement with LAMPOON: new insights from post-procedure imaging.

Keshav Kohli, Zhenglun Alan Wei, Vahid Sadri, Jaffar M Khan, John C Lisko, Tiffany Netto, Adam B Greenbaum, Philipp Blanke, John N Oshinski, Robert J Lederman and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  8. Use of Electrosurgery in Interventional Cardiology.Interventional cardiology clinics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keshav KohliWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA.ORCID 0000-0002-1469-4088
Zhenglun Alan WeiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA.
Vahid SadriWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA.
Jaffar M KhanCardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
John C LiskoStructural Heart and Valve Center, Emory University Hospital, Atlanta, GA, USA.
Tiffany NettoWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA.
Adam B GreenbaumStructural Heart and Valve Center, Emory University Hospital, Atlanta, GA, USA.
Philipp BlankeDepartment of Radiology, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, CA.
John N OshinskiDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA, USA.
Robert J LedermanCardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1202-6673
Ajit P YoganathanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA.
Vasilis C BabaliarosStructural Heart and Valve Center, Emory University Hospital, Atlanta, GA, USA.

Funding

Novel catheter treatment of valve diseaseZIAHL006040 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$23.6M
American Heart Association predoctoral 20PRE35200392Wallace H. Coulter chair funds
6 · The paper itself

Abstract

aimsTo characterize the dynamic nature of the left ventricular outflow tract (LVOT) geometry and flow rate in patients following transcatheter mitral valve replacement (TMVR) with anterior leaflet laceration (LAMPOON) and derive insights to help guide future patient selection. METHODS AND

resultsTime-resolved LVOT geometry and haemodynamics were analysed with post-procedure computed tomography and echocardiography in subjects (N = 19) from the LAMPOON investigational device exemption trial. A novel post hoc definition for LVOT obstruction was employed to account for systolic flow rate and quality of life improvement [obstruction was defined as LVOT gradient >30 mmHg or LVOT effective orifice area (EOA) ≤1.15 cm2]. The neo-LVOT and skirt neo-LVOT were observed to vary substantially in area throughout systole (64 ± 27% and 25 ± 14% change in area, respectively). The peak systolic flow rate occurred most commonly just prior to mid-systole, while minimum neo-LVOT (and skirt neo-LVOT) area occurred most commonly in early-diastole. Subjects with LVOT obstruction (n = 5) had smaller skirt neo-LVOT values across systole. Optimal thresholds for skirt neo-LVOT area were phase-specific (260, 210, 200, and 180 mm2 for early-systole, peak flow, mid-systole, and end-systole, respectively).

conclusionThe LVOT geometry and flow rate exhibit dynamic characteristics following TMVR with LAMPOON. Subjects with LVOT obstruction had smaller skirt neo-LVOT areas across systole. The authors recommend the use of phase-specific threshold values for skirt neo-LVOT area to guide future patient selection for this procedure. LVOT EOA is a 'flow-independent' metric which has the potential to aid in characterizing LVOT obstruction severity.

Indexed as

Heart Valve ProsthesisHeart Valve Prosthesis ImplantationVentricular Outflow ObstructionCardiac CatheterizationHumansMitral ValveQuality of LifeLAMPOONleft ventricular outflow tract obstructionneo-LVOTTMVRtranscatheter electrosurgerytranscatheter mitral valve replacement

Identifiers

PMID34009283
PMCPMC9630868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.