Evidence map›Paper›PMID 34009260›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot.

Sarah U Morton, Lara Maleyeff, David Wypij, Hyuk Jin Yun, Caitlin K Rollins, Christopher G Watson, Jane W Newburger, David C Bellinger, Amy E Roberts, Michael J Rivkin and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. [Research progress on neurodevelopmental disorders associated with congenital heart disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot.Computational and mathematical methods in medicine · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sarah U MortonDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Lara MaleyeffDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
David WypijDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Hyuk Jin YunDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Caitlin K RollinsDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
Christopher G WatsonDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
Jane W NewburgerDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
David C BellingerDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
Amy E RobertsDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Michael J RivkinDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
P Ellen GrantDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Kiho ImDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Boston Children's Hospital · USHarvard University · US

Funding

SSCOR in Pediatric Heart Development and DiseaseP50HL074734 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2004 to 2008
$19.9M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Longitudinal Study of childhood fMRI markers prior to reading onsetR01HD065762 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GAAB, NADINE, GRANT, PATRICIA ELLEN · 2011 to 2021
$6.3M
Advanced Fetal ImagingR01EB017337 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI ADALSTEINSSON, ELFAR, GRANT, PATRICIA ELLEN · 2014 to 2018
$6.2M
The Boston Circulatory Arrest Study - Antecedents and Correlates of Well-Being in Adults with Congenital Heart DiseaseR01HL135061 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI GURVITZ, MICHELLE · 2017 to 2020
$3.1M
Brain Structure and Function in Adolescents after the Fontan OperationR01HL096825 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., RIVKIN, MICHAEL JOHN · 2009 to 2012
$2.9M
Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseR01NS114087 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2020 to 2024
$2.8M
Fetal Brain Development in Congenital Heart DiseaseK23NS101120 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROLLINS, CAITLIN · 2017 to 2022
$1.1M
NHLBI NIH HHS P50 HL074734NHLBI NIH HHS R01 HL096825NHLBI NIH HHS R01 HL135061NIBIB NIH HHS R01 EB017337NICHD NIH HHS P50 HD105351NICHD NIH HHS R01 HD065762NIH HHS K23-NS101120NINDS NIH HHS K23 NS101120NINDS NIH HHS R01 NS114087
6 · The paper itself

Abstract

Neurodevelopmental disabilities are the most common noncardiac conditions in patients with congenital heart disease (CHD). Executive function skills have been frequently observed to be decreased among children and adults with CHD compared with peers, but a neuroanatomical basis for the association is yet to be identified. In this study, we quantified sulcal pattern features from brain magnetic resonance imaging data obtained during adolescence among 41 participants with tetralogy of Fallot (ToF) and 49 control participants using a graph-based pattern analysis technique. Among patients with ToF, right-hemispheric sulcal pattern similarity to the control group was decreased (0.7514 vs. 0.7553, P = 0.01) and positively correlated with neuropsychological testing values including executive function (r = 0.48, P < 0.001). Together these findings suggest that sulcal pattern analysis may be a useful marker of neurodevelopmental risk in patients with CHD. Further studies may elucidate the mechanisms leading to different alterations in sulcal patterning.

Indexed as

Executive FunctionAdolescentAdultBrainCase-Control StudiesCerebral CortexChildDevelopmental DisabilitiesFemaleHeart Defects, CongenitalHumansMagnetic Resonance ImagingMaleNeuropsychological TestsTetralogy of FallotYoung Adultcongenital heart diseaseexecutive functionmagnetic resonance imagingsulcal patterntetralogy of Fallot

Identifiers

PMID34009260
PMCPMC8408447
OpenAlexW3157235777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.