Evidence map›Paper›PMID 34009243›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

Resting-State Functional Connectivity and Psychopathology in Klinefelter Syndrome (47, XXY).

Ethan T Whitman, Siyuan Liu, Erin Torres, Allysa Warling, Kathleen Wilson, Ajay Nadig, Cassidy McDermott, Liv S Clasen, Jonathan D Blumenthal, François M Lalonde and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. New waves in psychiatric neuroimaging.Nature neuroscience · 2026
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ethan T WhitmanSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Siyuan LiuSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Erin TorresSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Allysa WarlingSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Kathleen WilsonSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Ajay NadigSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Cassidy McDermottSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Liv S ClasenSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Jonathan D BlumenthalSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
François M LalondeSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
Stephen J GottsSection on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20814, USA.
Alex MartinSection on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20814, USA.
Armin RaznahanSection on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD 20814, USA.
National Institute of Mental Health · US

Funding

Section on Developmental NeurogenomicsZIAMH002949 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RAZNAHAN, ARMIN · 2016 to 2025
$30.0M
The Neural Foundations for Memory and Social Cognition In The Human BrainZIAMH002588 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MARTIN, ALEX · 2009 to 2025
$21.1M
National Institutes of Mental Health Intramural Research Program NCT00001246NIH Annual Report ZIAMH002949-03
6 · The paper itself

Abstract

Klinefelter syndrome (47, XXY; henceforth: XXY syndrome) is a high-impact but poorly understood genetic risk factor for neuropsychiatric impairment. Here, we provide the first study to map alterations of functional brain connectivity in XXY syndrome and relate these changes to brain anatomy and psychopathology. We used resting-state functional magnetic resonance imaging data from 75 individuals with XXY and 84 healthy XY males to 1) implement a brain-wide screen for altered global resting-state functional connectivity (rsFC) in XXY versus XY males and 2) decompose these alterations through seed-based analysis. We then compared these rsFC findings with measures of regional brain anatomy, psychopathology, and cognition. XXY syndrome was characterized by increased global rsFC in the left dorsolateral prefrontal cortex (DLPFC)-reflecting DLPFC overconnectivity with diverse rsFC networks. Functional overconnectivity was partly coupled to co-occurring regional volumetric changes in XXY syndrome, and variation in DLPFC-precuneus rsFC was correlated with the severity of psychopathology. By providing the first view of altered rsFC in XXY syndrome and contextualizing observed changes relative to neuroanatomy and behavior, our study helps to advance biological understanding of XXY syndrome-both as a disorder in its own right and more broadly as a model of genetic risk for psychopathology.

Indexed as

AdolescentChildChromosomes, Human, XChromosomes, Human, YFemaleHumansIntelligence TestsKlinefelter SyndromeMagnetic Resonance ImagingMaleMental DisordersNeural PathwaysNeuroimagingParietal LobePrefrontal CortexYoung AdultaneuploidyfMRIsex chromosomeX-chromosomeXXY syndrome

Identifiers

PMID34009243
PMCPMC8485146
OpenAlexW3157261061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.